Chiral Separation Techniques

A Practical Approach
Author: Ganapathy Subramanian
Publisher: John Wiley & Sons
ISBN: 352761172X
Category: Science
Page: 641
View: 1381
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Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.

A practical approach to chiral separations by liquid chromatography


Author: G. Subramanian
Publisher: Wiley-VCH
ISBN: N.A
Category: Science
Page: 405
View: 9266
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Both analytical and preparative-scale enantioseparation techniques are covered in a down-to-earth practical way. The most important aspects of design, economics and safety are considered with emphasis on current European and North American legislation. In addition, the theory of chiral separation is covered in sufficient detail to guide the practising chromatographer interested in developing new techniques. A team of experts from academic and industrial laboratories throughout the world have compiled their findings and experience to make this book an exceptionally timely and unique contribution to the field.

Chiral Recognition in Separation Methods

Mechanisms and Applications
Author: Alain Berthod
Publisher: Springer Science & Business Media
ISBN: 9783642124457
Category: Science
Page: 337
View: 9231
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What drives a scientist to edit a book on a speci c scienti c subject such as chiral mechanisms in separation methods? Until December 2005, the journal Analytical Chemistry of the American Chemical Society (Washington, DC) had an A-page section that was dedicated to simple and clear presentations of the most recent te- niques or the state of the art in a particular eld or topic. The “A-page” section was prepared for a broad audience of chemists including industrial professionals, s- dents as well as academics looking for information outside their eld of expertise. 1 Daniel W. Armstrong, one of the editors of this journal and a twenty-year+ long friend, invited me to present my view on chiral recognition mechanisms in a simple and clear way in an “A-page” article. In 2006, the “A-page” section was maintained as the rst articles at the beginning of each rst bi-monthly issue but the pagination was no longer page distinguished from the regular research articles published by the journal. During the time between the invitation and the submission, the A-page section was integrated into the rest of the journal and the article appeared as (2006) Anal Chem (78):2093–2099.

HPLC richtig optimiert

Ein Handbuch für Praktiker
Author: Stavros Kromidas
Publisher: John Wiley & Sons
ISBN: 3527660356
Category: Science
Page: 810
View: 3239
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Neben der Methodenentwicklung ist die Optimierung bestehender Methoden eine zentrale Aufgabe im HPLC-Labor. Eine Aufgabe, die heute in immer kurzerer Zeit und kosteneffizient erledigt werden muss. Das Handbuch bietet eine fundierte Hilfe, um diese Herausforderung noch besser zu meistern. International renommierte Autoren behandeln sowohl die allgemeinen Grundlagen und Strategien der Optimierung als auch die spezifischen Aspekte der unterschiedlichen Techniken wie RP-HPLC, NP-HPLC, Micro- und Nano-HPLC sowie der Kopplungstechniken wie LC-MS. Auch die richtige Saulenauswahl sowie Enantiomerentrennungen gehoren zu den behandelten Themen. Die Autoren liefern konkrete, praktische Tipps ebenso wie relevante Hintergrundinformationen. Sie bieten daruber hinaus Einblicke in die Optimierungspraxis sieben international renommierter Firmen verschiedener Branchen. Einige Beitrage stellen die Anwendung gangiger Optimierungssoftware wie DryLab oder ChromSword dar. Das ganze wird abgerundet durch praxisnahe Berichte erfahrener Anwender aus den verschiedenen Anwendungsgebieten, inbesondere aus den Life Sciences, wie beispielsweise Proteomics oder Pharmaentwicklung. Alle Beitrage sind in einem auf das Wesentliche konzentrierten und anwendungsnahen Stil geschrieben. Der Aufbau des Buches mit abgeschlossenen Kapiteln erleichtert das gezielte Nachschlagen.

Chiral Separation Methods for Pharmaceutical and Biotechnological Products


Author: Satinder Ahuja
Publisher: John Wiley & Sons
ISBN: 9781118097755
Category: Science
Page: 400
View: 6383
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Discusses chiral separations and offers guidance for selectingthe optimum method for desired results Chiral separations represent the most intriguing and, by somemeasures, most difficultseparations of chemical compounds. Thisbook provides researchers and students an under-standing of chiralseparations and offers a convenient route to selecting the bestseparation method, saving considerable time and cost in productdevelopment. Considering chiral separations in the biotechnological andpharmaceutical industries, as well as for food applications, Dr.Ahuja provides insights into a broad range of topics. Opening witha broad overview of chiral separations, regulatory considerationsin drug product development, and basic issues in methoddevelopment, the book: Covers a variety of modern methods such as gas chromatography,high performance liquid chromatography, supercritical fluidchromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity ofsmall and large molecules Provides detailed information on useful chiral stationary phases(CSPs) for HPLC Includes handy information on selection of an appropriate CSP,including mechanistic studies Offers strategies for fast method development with HPLC, SFC,and CE Discusses preparatory methods utilized in the pharmaceuticalindustry With in-depth discussions of the current state of the field aswell as suggestions to assist future developments, ChiralSeparation Methods for Pharmaceutical and BiotechnologicalProducts is an essential text for laboratory investigators,managers, and regulators who are involved in chiral separations inthe pharmaceutical industry, as well as students preparing forcareers in these fields.

Stereoselective Synthesis of Drugs and Natural Products


Author: Vasyl Andrushko,Natalia Andrushko
Publisher: John Wiley & Sons
ISBN: 1118628330
Category: Science
Page: 1836
View: 744
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Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.

Thermodynamic and Kinetic Characterization of Chiral Separations with ß-cyclodextrin Stationary Phase


Author: Xiaoping Li
Publisher: N.A
ISBN: N.A
Category: Chirality
Page: 572
View: 6431
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Chiral Separations By Liquid Chromatography And Related Technologies


Author: Hassan Y. Aboul-Enein,Imran Ali
Publisher: CRC Press
ISBN: 9780203911112
Category: Science
Page: 400
View: 9728
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Unique in its systematic and detailed description of the various types, structures, and properties of chiral stationary phases (CSPs) and their preparation, application, and future scope, this volume highlights an assortment of liquid chromatographic approaches, including sub- and super-critical fluid chromatography, capillary electrochromatography, and thin layer chromatography. Readers will find: viable optimization techniques for enantiomeric resolution on various types of CSPs and new strategies in liquid chromatography and related technologies of chiral separations. It is a valuable resource filled with 1200 of the most recent and relevant literature citations.

Chiral Analysis


Author: Kenneth W. Busch,Marianna A. Busch
Publisher: Elsevier Science Limited
ISBN: N.A
Category: Science
Page: 704
View: 9920
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Chiral Analysis covers an important area of analytical chemistry of relevance to a wide variety of scientific professionals. The target audience is scientific professionals with an undergraduate background in chemistry or a related discipline, specifically organic chemists, researchers in drug discovery, pharmaceutical researchers involved with process analysis or combinatorial libraries, and graduate students in chemistry. Chapters have been written with the nonspecialist in mind so as to be self-contained. * Broad coverage - spectroscopic and separation methods covered in a single volume * Up-to-date and detailed review of the various techniques available and/or under development in this field * Contributions from leading experts in the field

Chromatography

fundamentals and applications of chromatography and related differential migration methods
Author: Erich Heftmann
Publisher: Elsevier Science Ltd
ISBN: N.A
Category: Science
Page: 1156
View: 9781
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Chromatography has emerged as the most important and versatile analytical method. The book is not only an updated version of Heftmann's classical text, but it covers areas of future importance, such as microfluidics and computer resources. Under his experienced guidance, authorities in each field have contributed their practical experience to an integrated treatment of modern micro analysis. In Part A the theoretical basis of individual separation methods is explained and the technical aspects are illustrated. It includes the theory of gas and liquid chromatography as well as specific chromatographic techniques, such as size-exclusion, planar, ion, and affinity chromatography as well as various electrokinetic separation techniques. Microfluidics are covered fotr the first time and useful sources of analytical instruments are listed and evaluated. Part B brings the traditional field of application up to date. These include amino acids and proteins, nucleic acids and their constituents, lipid, and carbohydrates. Special chapters are devoted to the most important areas of application: drug and environmental analysis. Forensic and phytochemical applications are covered for the first time. Together with an overview of computer resources, the subject index allows novices as well as experts to obtain rapid and authoritative guidance to analytical problems, such as choice of methods and optimization of techniques and instrumentation.

Journal


Author: American Chemical Society
Publisher: N.A
ISBN: N.A
Category: Chemistry
Page: N.A
View: 3022
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Design of High Performance Polymeric Materials for Molecular Recognition


Author: Frank Hiroshi Ling
Publisher: N.A
ISBN: N.A
Category:
Page: 322
View: 6176
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Bulletin of the Korean Chemical Society


Author: N.A
Publisher: N.A
ISBN: N.A
Category: Chemistry
Page: N.A
View: 5016
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Chiral Separations

Methods and Protocols
Author: Gerald Gübitz,Martin G. Schmid
Publisher: Springer Science & Business Media
ISBN: 1592596487
Category: Science
Page: 448
View: 6968
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Prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale. Described in step-by-step detail to ensure successful experimental results, the procedures are presented as either general methods or as specific applications to substance classes and special compounds, with emphasis on high performance liquid chromatography and capillary electrophoresis techniques, but also including thin layer chromotographic, gas chromatographic, supercritical fluid chromatographic as well as recent electrochromotographic techniques.

Seminars in Organic Synthesis

XXVIII Summer School "A. Corbella"
Author: Gabriele Renzi,Enrico Marcantoni
Publisher: Royal Society of Chemistry
ISBN: 9788886208277
Category: Science
Page: 408
View: 6454
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The latest volume in this respected series encompasses subjects as diverse as materials with optical or biological properties, chiral molecules, advanced physical methods in organic synthesis and non-classical synthetic methodologies. Critical surveys are presented on: total synthesis of natural products; organometallic compounds in organic synthesis; the introduction and transformation of functional groups; and solid supported synthesis. The accompanying CD-ROM provides pdf files of the articles included in the book. This volume will be an invaluable reference source for students and researchers in both academia and industry.

International Books in Print


Author: N.A
Publisher: N.A
ISBN: N.A
Category: English imprints
Page: N.A
View: 3703
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Applied Spectroscopy


Author: N.A
Publisher: N.A
ISBN: N.A
Category: Spectrum analysis
Page: N.A
View: 1192
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Chiral Environmental Pollutants

Trace Analysis and Ecotoxicology
Author: R. Kallenborn,H. Hühnerfuss
Publisher: Springer Science & Business Media
ISBN: 9783540664239
Category: Science
Page: 210
View: 4430
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This monograph contains a survey on the role of chirality in ecotoxicological processes. The focus is on environmental trace analysis. Areas such as toxicology, ecotoxicology, synthetic chemistry, biology, and physics are also covered in detail in order to explain the different properties of enantiomers in environmental samples. This monograph delivers a comprehensive survey for environmental trace analysts, analytical chemists, ecotoxicologists, food scientists and experienced lab workers.

Stereoselective Synthesis

A Practical Approach
Author: Mihály Nógrádi
Publisher: John Wiley & Sons
ISBN: 3527615687
Category: Science
Page: 386
View: 5700
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The state-of-the-art in stereoselective synthesis! Thoroughly revised and updated, this enlarged second edition offers a plethora of valuable information on methods and reagents in stereoselective synthesis. Methods have been selected for high efficiency and selectivity; mechanistic aspects are treated succinctly, with a strong emphasis on practical applications. For this new edition, material has been added on * homogeneous diastereoselective hydrogenations * enantioselective oxidations * novel, efficient chiral auxiliaries Much of the information given is presented in figures and tables, which makes the book a valuable reference work for the practically minded organic chemist. From reviews of the first edition: 'The extensive material in the volume should prove particularly useful to anyone involved in synthetic chemistry or teaching a course in organic chemistry.' Journal of Medicinal Chemistry 'With nearly 1400 references cited, the book contains a wealth of information and should be a useful addition to the chemist's library.' The American Scientist

Journal of Chromatography


Author: N.A
Publisher: N.A
ISBN: N.A
Category: Chromatographic analysis
Page: N.A
View: 6613
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