Diagnostic Molecular Pathology

A Guide to Applied Molecular Testing
Author: William B. Coleman,Gregory J. Tsongalis
Publisher: Academic Press
ISBN: 0128011572
Category: Science
Page: 582
View: 335
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Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). In each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. Sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described. The book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). In addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests. Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. Readers are directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions. Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis, and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for prognostication of disease Features an ancillary website with self-testing exercises where decision trees can be employed to simulate actual clinical decisions Highlights new technologies and approaches of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests

Immunology & Serology in Laboratory Medicine - E-Book


Author: Mary Louise Turgeon
Publisher: Elsevier Health Sciences
ISBN: 0323402836
Category: Medical
Page: N.A
View: 3168
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Immunology & Serology in Laboratory Medicine - E-Book

Taschenatlas der Genetik


Author: Eberhard Passarge
Publisher: N.A
ISBN: 9783137595021
Category:
Page: 435
View: 3537
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Molecular Pathology


Author: John M. S. Bartlett,Abeer Shaaban,Fernando Schmitt
Publisher: Cambridge University Press
ISBN: 1107443466
Category: Medical
Page: 400
View: 8221
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Practical overview of current molecular techniques and their applications in each organ system, for practising and trainee pathologists.

Diagnostic Molecular Pathology in Practice

A Case-Based Approach
Author: Iris Schrijver
Publisher: Springer Science & Business Media
ISBN: 9783642196775
Category: Medical
Page: 339
View: 1570
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This entirely case-based book covers a broad cross-section of the practical issues frequently encountered in the day-to-day activities of a molecular genetic pathologist. The book is divided into four sections on the principal areas addressed in molecular genetic pathology (MGP): inherited diseases, hematopathology, solid tumors, and infectious diseases. The topics covered by the cases in each section include test selection, qualitative and quantitative laboratory techniques, test interpretation, prognostic and therapeutic considerations, ethical considerations, technical troubleshooting, and result reporting. This book will be ideal for trainees in MGP and clinical molecular genetics who require a practice-based preparation for board examinations. It will also be very useful for residents and fellows in medical specialties to which MGP is pertinent, and for practicing pathologists who want to learn more about the current practice of molecular diagnostics.

Medizinische Mikrobiologie


Author: Ernest Jawetz,Joseph L. Melnick,Edward A. Adelberg
Publisher: Springer-Verlag
ISBN: 3662001551
Category: Science
Page: N.A
View: 3179
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Die Autoren haben beabsichtigt, diejenigen Gebiete der medizinischen Mikrobiologie kurz, exakt und in ihrem gegenwärtigen Stand darzustellen, die für die Infektionskrankheiten und ihre Chemotherapie von besonderer Bedeutung sind. Das Buch wendet sich in erster Linie an Medizinstudenten, außerdem an alle Ärzte in Krankenhaus und Praxis. Die Notwendigkeit für ein klares Verständnis der mlkrobiologischen Grundtatsachen ist in den letzten Jahren stärker geworden, da in Biochemie, Virologie und Chemotherapie so wie auf weiteren, die Medizin beeinflussenden Gebieten bedeutende Entwicklungen statt gefunden haben. Ein wesendicher Teil dieses Lehrbuches ist deswegen der Darstellung der Grundlagen gewidmet, wodurch sich das Buch auch für die Einführung des Studenten in den mikrobiologischen Kurs als brauchbar erweisen wird. Für die neue Auflage wurde ein Kapitel über Virus und Krebs neu geschrieben, und das Kapitel über antimikrobielle Chemotherapie wurde von Grund auf neu bearbeitet. Die Autoren freuen sich, bei dem Erscheinen der 7. amerikanischen Ausgabe von einer spanischen, deutschen, italienischen und griechischen Ausgabe, sowie von der Vorbereitung für eine serbokroatische Übersetzung berichten zu können. Die Autoren möchten nochmals allen danken, die ihnen bei der Bearbeitung dieser Auf lage behilflich waren, und die es ihnen durch ihre Kommentare und ihre Kritik ermöglicht haben, die in 2jährigen Abständen erscheinenden Revisionen dieses Buches auf dem neu esten Stand zu halten. ERNEsr JAWETZ JOSEPH L MELNICK San Frandsco, August 1966 EnWARD A AnELBERG III Inhaltsverzeichnis 1 Kapitell Die ~lt der Mikroben 8 Kapitel 2 Cytologie der Bakterien Optische Methoden 8 9 Eukaryote Zellstrukturen Prokaryote Zellstrukturen . 12 14 Cytoplasmatische Strukturen. 27 Färbeverfahren .

Precision Molecular Pathology of Neoplastic Pediatric Diseases


Author: Larissa V. Furtado,Aliya N. Husain
Publisher: Springer
ISBN: 3319896261
Category: Medical
Page: 360
View: 8598
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This book provides a comprehensive, state-of-the art review of pediatric oncology. The text covers relevant concepts in molecular biology and addresses technical principles, applications, challenges, and integration of current and emerging genomic and molecular methods in the diagnosis and personalized management of childhood cancers. The text also discusses a wide array of pediatric neoplasms in the context of molecular pathology in a concise and understandable manner, with focus on their molecular pathogenesis, clinicopathological features, classification, molecular diagnosis, and approaches to personalized care. Written by experts in the field, Precision Molecular Pathology of Neoplastic Pediatric Diseases serves as a valuable resource for pathologists, pediatric oncologists, trainees and researchers with an interest in pediatric and molecular pathology.

Abeloff's Clinical Oncology E-Book


Author: John E. Niederhuber,James O. Armitage,James H Doroshow,Michael B. Kastan,Joel E. Tepper
Publisher: Elsevier Health Sciences
ISBN: 1455728810
Category: Medical
Page: 2224
View: 959
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Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.

Cell and Tissue Based Molecular Pathology

A Volume in the Foundations in Diagnostic Pathology Series
Author: Raymond R. Tubbs,Mark H. Stoler
Publisher: Elsevier Health Sciences
ISBN: 1437719481
Category: Medical
Page: 452
View: 4882
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This volume in the Foundations in Diagnostic Pathology Series packs today's most essential cell and tissue base molecular pathology into a compact, high-yield format! It focuses on the state of the art in practical validated molecular diagnostics as applied across the fields of surgical pathology and cytology. With an emphasis on current, clinically valid, and diagnostically important applications today and in the near future, you can be assured you’re getting the most up-to-date, authoritative coverage available. Its pragmatic, well-organized approach, nearly 250 full-color illustrations, and at-a-glance boxes and tables make the information you need easy to access. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice! Offers detailed discussions on today’s technologies to help you select the best test for case evaluation. Presents recognized molecular pathologists who convey the most current information, keeping you on the cusp of your field. Features nearly 250 full-color illustrations that present important pathologic features, enabling you to form a differential diagnosis and compare your findings with actual cases. Uses a consistent, user-friendly format, including at-a-glance boxes and tables for easy reference.

Die Cellularpathologie in Ihrer Begründung Auf Physiologische Und Pathologische Gewebelehre


Author: Rudolf Ludwig Karl Virchow
Publisher: Wentworth Press
ISBN: 9780270274080
Category:
Page: 494
View: 5406
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This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Molecular Pathology in Drug Discovery and Development


Author: J. Suso Platero
Publisher: John Wiley & Sons
ISBN: 9780470475942
Category: Medical
Page: 376
View: 5871
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Covers powerful new tools for drug development Molecular pathology offers tools and techniques that can greatly enhance the drug discovery and development process, helping to make the promises of personalized medicine a reality. Molecular Pathology in Drug Discovery and Development provides an unmatched guide to this cutting-edge discipline and its applications to pharmaceutical science. With contributions from leading lights in drug discovery, drug development, and molecular pathology balanced by a consistent editorial approach, this reference offers both an overview of molecular pathology and a close look at the methods as they are applied to the process of drug discovery and development. Presented as steps in the drug development process, the coverage includes the use of molecular pathology to: Identify and validate new drug candidates Enhance transcriptional profiling to better find and validate biomarkers Assess toxicology Employ toxicogenomics to identify genes relevant to the safety of compounds Identify correct doses for different drugs Identify patients for treatment Develop molecular therapies Further the new techniques of Immunohistochemistry and Immunofluorescence With many tests and treatments already working today, drug research and development using molecular pathology has shown itself an extremely fruitful area. Molecular Pathology in Drug Discovery and Development gives practitioners an up-to-date resource on this highly active discipline and its role in furthering pharmaceutical research.

Henry's Clinical Diagnosis and Management by Laboratory Methods E-Book


Author: Richard A. McPherson,Matthew R. Pincus
Publisher: Elsevier Health Sciences
ISBN: 1455726842
Category: Medical
Page: 1568
View: 5357
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Recognized as the definitive book in laboratory medicine since 1908, Henry’s Clinical Diagnosis and Management by Laboratory Methods, edited by Richard A. McPherson, MD and Matthew R. Pincus, MD, PhD, is a comprehensive, multidisciplinary pathology reference that gives you state-of-the-art guidance on lab test selection and interpretation of results. Revisions throughout keep you current on the latest topics in the field, such as biochemical markers of bone metabolism, clinical enzymology, pharmacogenomics, and more! A user-friendly full-color layout puts all the latest, most essential knowledge at your fingertips. Update your understanding of the scientific foundation and clinical application of today's complete range of laboratory tests. Get optimal test results with guidance on error detection, correction, and prevention as well as cost-effective test selection. Reference the information you need quickly and easily thanks to a full-color layout, many new color illustrations and visual aids, and an organization by organ system. Master all the latest approaches in clinical laboratory medicine with new and updated coverage of: the chemical basis for analyte assays and common interferences; lipids and dyslipoproteinemia; markers in the blood for cardiac injury evaluation and related stroke disorders; coagulation testing for antiplatelet drugs such as aspirin and clopidogrel; biochemical markers of bone metabolism; clinical enzymology; hematology and transfusion medicine; medical microbiology; body fluid analysis; and many other rapidly evolving frontiers in the field. Effectively monitor the pace of drug clearing in patients undergoing pharmacogenomic treatments with a new chapter on this groundbreaking new area. Apply the latest best practices in clinical laboratory management with special chapters on organization, work flow, quality control, interpretation of results, informatics, financial management, and establishing a molecular diagnostics laboratory. Confidently prepare for the upcoming recertification exams for clinical pathologists set to begin in 2016.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics - E-Book


Author: Carl A. Burtis,Edward R. Ashwood,David E. Bruns
Publisher: Elsevier Health Sciences
ISBN: 1455759422
Category: Medical
Page: 2256
View: 8316
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As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors, Ann Gronowski, W. Greg Miller, Michael Oellerich, Francois Rousseau, Mitchell Scott, and Karl Voelkerding, lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.

Diagnostic Molecular Pathology


Author: Debra G. B. Leonard
Publisher: Saunders
ISBN: 9780721600475
Category: Medical
Page: 208
View: 9628
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This practical guide provides information essential to understanding the significance of molecular biology and its application to everyday practice. Coverage focuses on the spectrum of currently used molecular tests in the areas of hematopathology, solid tumors, genetics, and identify testing. Examples of both molecular and cytogenetic assays demonstrate how these tests are used in today's pathology labs to detect a wide range of infectious diseases and inherited and metabolic conditions. Presents the full range of molecular diagnostic methods from the standpoint of their clinical applications and diagnostic value. Provides full-chapter coverage of each type of molecular testing, including genetics · carcinomas · sarcomas · leukemias and lymphomas · and identity testing. Concisely covers all areas of molecular pathology-making it the single source for all aspects of this field. Features the contributions of 12 leading experts in molecular pathology. Offers a complete introduction to molecular biology as well as common molecular methods of testing. Focuses on test utility as well as test interpretation and significance. With 11 additional contributors.

Diagnostic Techniques in Hematological Malignancies


Author: Wendy N. Erber
Publisher: Cambridge University Press
ISBN: 9781139491730
Category: Medical
Page: N.A
View: 2324
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The diagnosis and monitoring of hematological malignancies is complex and requires a systematic approach. Morphology, cell phenotyping, cytogenetics and molecular genetics are essential, and the results must be integrated. Diagnostic Techniques in Hematological Malignancies details the principles and applications of each of these test types in the diagnosis of hematological malignancies in blood and bone marrow. The first section describes the test modalities – including methodological principles, data interpretation and limitations – and is illustrated by clinical examples. The second section focuses on the clinical entities, detailing the most appropriate tests for diagnosis, staging and monitoring of different hematological malignancies and includes test utilization to identify prognostic markers and potential therapeutic targets. With contributions from multiple international experts, this illustrated book is an essential resource for qualified and trainee hematologists, oncologists, and pathologists. It's a practical and useful guide, providing a rational and structured approach to the laboratory assessment of hematological malignancies.

Handbook of Autopsy Practice


Author: Brenda L. Waters
Publisher: Springer Science & Business Media
ISBN: 1597451274
Category: Medical
Page: 596
View: 9260
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Handbook of Autopsy Practice, Fourth Edition is divided into three parts. Part I contains six new chapters in which the reader will find an assortment of tools that will increase the value of the autopsy. Included in the section are valuable resources and tools such as a sample next-of-kin letter, a quality assurance worksheet, new discourse on the dissection procedure which is accompanied by a worksheet and template for the gross description. There is also a new, detailed discussion of the safe handling of sharps, complete with photographs and the reader will also find the updated requirements of the Eye Bank of America and the U.S. Food and Drug Administration for ocular tissue transplantation. Part II has been updated with new diseases and recent references added. Practicing autopsy pathologists, residents and students are invited to review this alphabetical listing of disorders before each autopsy in order to re-acquaint themselves with what they might encounter. Part III provides a series of tables providing organ weights and body measurements for fetuses, children and adults. Handbook of Autopsy Practice Fourth Edition is an essential resource for clinicians, pathologists, residents and students who strive to hone their trade and increase the value of the autopsies they perform.

Pathology of the Skin E-Book


Author: J. Eduardo Calonje,Thomas Brenn,Alexander J Lazar,Phillip H. McKee
Publisher: Elsevier Health Sciences
ISBN: 0723437181
Category: Medical
Page: 1906
View: 6240
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McKee's Pathology of the Skin is the most complete, in-depth resource on dermatopathology, covering etiology, pathogenesis, disease mechanisms, and recent genetic, molecular, and basic science data. Drs. J. Eduardo Calonje, Thomas Brenn, Alexander Lazar, and Phillip McKee present new illustrations, updated chapters, and coverage of new entities such as lymphomas, cutaneous tissue tumors, diseases of the nail, and more in this extensively revised fourth edition. This new edition is an absolute must for practicing dermatopathologists and general pathologists who sign out skin biopsies. It has over 5,000 images and new chapters on the pathology of HIV/AIDS, conjunctival tumors, sentinel lymph node biopsies, laboratory techniques in dermatopathology and a section on the pathology of salivary gland tumors. Also, the chapters on disorders of keratinization and diseases of the nails have been completely updated. With access to the full text, image and video bank online at www.expertconsult.com, you'll have convenient access to the guidance you need to formulate the most accurate reports. Recognize all the histological variations of any skin condition through coverage that integrates dermatopathology, clinical correlations, and clinical photographs. Easily reference key points thanks to bulleted lists of clinical features and differential diagnosis tables. Diagnose accurately using over 5,000 histopathologic and clinical illustrations that demonstrate the range of histologic manifestations. Stay current with updated and expanded coverage of diseases of the nail, cutaneous connective tissue tumors, tumors of the lymphoreticular system, and conjunctiva specimens. Minimize errors and formulate accurate reports by applying up-to-date molecular research tools, classification guidelines, immunohistochemical practices, and more. Effectively correlate your findings with clinical features through all-new, high-quality illustrations—none repeated from the previous editions—for each diagnostic entity. Access the fully searchable text online at www.expertconsult.com, along with a downloadable image bank and a link to PathConsult.

Molecular Genetics and Personalized Medicine


Author: D. Hunter Best,Jeffrey J. Swensen
Publisher: Springer Science & Business Media
ISBN: 1617795305
Category: Medical
Page: 246
View: 5966
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Genetic testing has become commonplace, and clinicians are frequently able to use knowledge of an individual’s specific genetic differences to guide their course of action. Molecular Genetics and Personalized Medicine highlights developments that have been made in the field of molecular genetics and how they have been applied clinically. It will serve as a useful reference for physicians hoping to better understand the role of molecular medicine in clinical practice. In addition, it should also prove to be an invaluable resource for the basic scientist that wants to better understand how advances in the laboratory are being moved from the bench to the bedside. All chapters are written by experts in their fields and include the most up to date medical information. The authors simplify complex genetic concepts and focus on practical patient related issues. The book will be of great value to pathologists, hematologists/oncologists, clinical geneticists, high-risk obstetricians, general practitioners, and physicians in all other medical specialties who utilize genetic testing to direct therapy.