Introduction to Glycobiology


Author: Maureen E. Taylor,Kurt Drickamer
Publisher: Oxford University Press
ISBN: 0199569118
Category: Medical
Page: 283
View: 6753
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Introduction to Glycobiology reveals the true impact of the sugars on biological systems, explaining their function at the molecular, cellular, and organismal level and their clinical relevance.

Introduction to Glycobiology


Author: Maureen E. Taylor,Kurt Drickamer
Publisher: Oxford University Press, USA
ISBN: 9780199282784
Category: Science
Page: 255
View: 1883
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We are all familiar with sugar as a vital source of energy. Yet the biological importance of the sugars extends way beyond their value as a cellular fuel. Introduction to Glycobiology reveals the true impact of the sugars on biological systems, explaining their functions at the molecular, cellular, and organismal level. With a new two-part structure, the book leads us through the essential principles and concepts upon which the discipline is grounded, before exploring the diverse roles ofsugars throughout biological systems, including development, cell signalling, and protein trafficking. It also describes the importance of glycobiology in disease, and explains how an understanding of the link between the two is enabling us to develop new therapeutic strategies. Taking the student from the fundamental principles to the frontiers of the subject, and with more learning features to get the most from their studies, Introduction to Glycobiology remains the ideal resource for students and teachers alike. Online Resource Centre For Lecturers: - Full Colour figures to fully engage their students during classes. For Students: - Hyperlinks to the primary literature, and full articles from appropriate OUP journals, to facilitate access to these additional resources - 3D models of key structures, to help students visualize structures, and gain a proper appreciation of the link between structure and function. - Answers to problems, to aid assessment. - Updates - surveys of key developments in the field, provided on a six-monthly basis, to maintain the currency of the resource.

Essentials of Glycobiology


Author: Ajit Varki
Publisher: CSHL Press
ISBN: 9780879696818
Category: Science
Page: 653
View: 3833
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Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. They participate in activities as diverse as protein folding, leukocyte physiology, and microbial pathogenesis. Genetic defects in their assembly are at the root of a growing list of human diseases. Essentials of Glycobiology describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Bioinformatics for Glycobiology and Glycomics: An Introduction


Author: Claus-Wilhelm von der Lieth,Thomas Luetteke,Martin Frank
Publisher: John Wiley & Sons
ISBN: 9780470029602
Category: Medical
Page: 494
View: 7190
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This book is the first to be dedicated to the bioinformatics of carbohydrates and glycoproteins. It provides an introduction to this emerging field of science both for the experimentalist working in glycobiology and glycomics, and also for the computer scientist looking for background information for the development of highly sophisticated algorithmic approaches. The book provides an overview of the state-of-the-art in the field, with reviews on databases, and the tools in use for analysis, interpretation, and prediction of the structures of complex carbohydrates, and demonstrates the value of bioinformatics for glycobiology. The availability of comprehensive databases and corresponding bioinformatics tools, to access and analyse the large amounts of experimental data relating to the structure of carbohydrates, will be a prerequisite for the success of the large-scale glycomics projects that aim to decipher new, so far unknown, biological functions of glycans. Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis and experimental costs. For a complete understanding of the molecular processes in which carbohydrates are involved, such as protein–carbohydrate interactions and the impact of glycosylation on protein function, knowledge of the 3D structure of the carbohydrate, the protein–carbohydrate complex, or the glycoprotein is often indispensable. This book provides a thorough introduction into methods used for conformational analysis of carbohydrates. Key features: Describes bioinformatic approaches to handle carbohydrate-active enzymes and glycosylation. Provides an overview on bioinformatics tools that facilitate analysis of carbohydrate structures. Gives introduction into molecular modelling of carbohydrate 3D structure and carbohydrates contained in the Protein Databank. Assumes only a basic knowledge of biology and bioinformatics.

Marine Glycobiology

Principles and Applications
Author: Se-Kwon Kim
Publisher: CRC Press
ISBN: 1498709621
Category: Medical
Page: 520
View: 3505
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Marine glycobiology is an emerging and exciting area in the field of science and medicine. Glycobiology, the study of the structure and function of carbohydrates and carbohydrate-containing molecules, is fundamental to all biological systems and represents a developing field of science that has made huge advances in the last half-century. This book revolutionizes the concept of marine glycobiology, focusing on the latest principles and applications of marine glycobiology and their relationships.

Glycosciences

Status & Perspectives
Author: Hans-Joachim Gabius,Sigrun Gabius
Publisher: John Wiley & Sons
ISBN: 3527614729
Category: Science
Page: 659
View: 5366
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A comprehensive survey of the topic, ranging from basic molecular research to clinical applications. Critical reviews by leading experts in each field summarize the state of knowledge and discuss the anticipated benefits of novel approaches and strategies. These include the impact of modern analysis techniques on glycobiology, the use of synthetic neoglycoproteins, or the clinical consequences of new insights into the physiological role of lectins and glycoconjugates in pathology, oncology, immunity, neuroscience and reproduction medicine. Throughout, the aim is to separate realistic applications from mere hopes.

Transforming Glycoscience

A Roadmap for the Future
Author: National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Assessing the Importance and Impact of Glycomics and Glycosciences
Publisher: National Academies Press
ISBN: 0309260868
Category: Science
Page: 208
View: 1765
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A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans--also known as carbohydrates, saccharides, or simply as sugars--play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.

Microbial Glycobiology

Structures, Relevance and Applications
Author: Anthony P Moran
Publisher: Elsevier
ISBN: 9780080923246
Category: Science
Page: 1036
View: 9066
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This book presents in an easy-to-read format a summary of the important central aspects of microbial glycobiology, i.e. the study of carbohydrates as related to the biology of microorganisms. Microbial glycobiology represents a multidisciplinary and emerging area with implications for a range of basic and applied research fields, as well as having industrial, medical and biotechnological implications. Individual chapters provided by leading international scientists in the field yield insightful, concise and stimulating reviews Provides researchers with an overview and synthesis of the latest research Each chapter begins with a brief 200 word Summary/Abstract detailing the topic and focus of the chapter, as well as the concepts to be addressed Allows researchers to see at a glance what each chapter will cover Each chapter includes a Research Focus Box Identifies important problems that still need to be solved and areas that require further investigation

Handbook of Glycomics


Author: Richard D. Cummings,J. Michael Pierce
Publisher: Academic Press
ISBN: 9780080920054
Category: Science
Page: 512
View: 1588
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The Handbook of Glycomics provides the first comprehensive overview of the emerging field of glycomics, defined as the study of all complex carbohydrates in an organism or cell ("the glycome"). Beginning with analytic approaches and bioinformatics, this work provides a detailed discussion of relevant databases, data integration, and analysis. It then moves on to a discussion of specific model organism and pathogen glycomes followed by therapeutic approaches to human disorders of glycosylization. Structure and function of glycomes are included along with state-of-the-art technologies and systems approaches to the analysis of glycans. Synthesizes contributions from experts in biology, chemistry, bioinformatics, biotechnology, and medicine Highlights chapters devoted to chemical synthesis, cancer glycomics and immune cell glycomics Includes discussions of proteomics, mass spectrometry, NMR, array technology, and transcriptomics analytic approaches

Glycome Informatics

Methods and Applications
Author: Kiyoko F. Aoki-Kinoshita
Publisher: CRC Press
ISBN: 1420083368
Category: Science
Page: 256
View: 6866
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A Focused, State-of-the-Art Overview of This Evolving Field Presents Various Techniques for Glycoinformatics The development and use of informatics tools and databases for glycobiology and glycomics research have increased considerably in recent years. In addition to accumulating well-structured glyco-related data, researchers have now developed semi-automated methods for the annotation of mass spectral data and algorithms for capturing patterns in glycan structure data. These techniques have enabled researchers to gain a better understanding of how these complex structures affect protein function and other biological processes, including cancer. One of the few up-to-date books available in this important area, Glycome Informatics: Methods and Applications covers all known informatics methods pertaining to the study of glycans. It discusses the current status of carbohydrate databases, the latest analytical techniques, and the informatics needed for rapid progress in glycomics research. Providing an overall understanding of glycobiology, this self-contained guide focuses on the development of glycome informatics methods and current problems faced by researchers. It explains how to implement informatics methods in glycobiology. The author includes the required background material on glycobiology as well as the mathematical concepts needed to understand advanced mining and algorithmic techniques. She also suggests project themes for readers looking to begin research in the field.

Glycobiology and Human Diseases


Author: Gherman Wiederschain
Publisher: CRC Press
ISBN: 1498709192
Category: Medical
Page: 334
View: 3672
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This book discusses glycobiology and various forms of human diseases. Topics covered include immunoglobulins, inflammation and glycosylation, the role and therapeutic significance of natural anti-glycan antibodies in malignancies and in normal and aberrant pregnancy, identifying urinary glycans as a possible method for the diagnosis of lysosomal storage diseases, glycobiology of human milk (biological roles and diseases) and pectins as biological modulators of human physiological reactions. The book includes analysis of comprehensive data and some productive conclusions and perspectives.

Introduction to Bioorganic Chemistry and Chemical Biology


Author: David Van Vranken,Gregory A. Weiss
Publisher: Garland Science
ISBN: 1135054827
Category: Medical
Page: 504
View: 1666
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Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.

Comprehensive Glycoscience, Four-Volume Set

from Chemistry to Systems Biology
Author: N.A
Publisher: Elsevier Science
ISBN: 9780444519672
Category: Science
Page: 3600
View: 2925
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Carbohydrates are an important part of life and are present in bacteria, fungi, viruses, yeast, plants, animals and humans. The rapid expansion of chemistry and glycobiology over the last few years has provided many new, imaginative and efficient techniques which provide further insight into the structures and biological interactions of carbohydrates and glycostructures. This work has a very broad scope and will appeal to a wide audience as it explores the interactions between biology, chemistry and molecular biology towards understanding, synthesising and developing glycoproteins, glycolipids, proteoglyans and polysaccharides, which are important molecules in nature for controlling health and disease and food and feed. Glycocompounds reviewed include: oligosaccharides, polysaccharides, glycoproteins, glycolipids, glycoconjugates, lectins, cellulose, pectins and starch. Topics covered include: spectroscopy, nomenclature, structures, synthesis, biosynthesis, molecular interactions, degradation, biochemistry, glycobiology, glycotherapeutics and diseases. · Combines multiple aspects of glycoscience in one comprehensive work · Documents the new and rapid expansion of carbohydrate chemistry and glycobiology over the last few years · Highlights the many new, imaginative and efficient techniques for providing insights into carbohydrates and glycostructures

Carbohydrates: The Essential Molecules of Life


Author: Robert V. Stick,Spencer Williams
Publisher: Elsevier
ISBN: 9780080927022
Category: Science
Page: 496
View: 2224
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This book provides the "nuts and bolts" background for a successful study of carbohydrates - the essential molecules that not only give you energy, but are an integral part of many biological processes. A question often asked is 'Why do carbohydrate chemistry?' The answer is simple: It is fundamental to a study of biology. Carbohydrates are the building blocks of life and enable biological processes to take place. Therefore the book will provide a taste for the subject of glycobiology. Covering the basics of carbohydrates and then the chemistry and reactions of carbohydrates this book will enable a chemist to gain essential knowledge that will enable them to move smoothly into the worlds of biochemistry, molecular biology and cell biology. * includes perspective from new co-author Spencer Williams, who enhances coverage of the connection between carbohydrates and life * describes the basic chemistry and biology of carbohydrates * reviews the concepts, synthesis, reactions, and biology of carbohydrates

Introduction to Bioorganic Chemistry and Chemical Biology


Author: David Van Vranken,Gregory A. Weiss
Publisher: Garland Science
ISBN: 1135054827
Category: Medical
Page: 504
View: 4556
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Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.

Glycobiology of the Nervous System


Author: Robert Yu,Cara-Lynne Schengrund
Publisher: Springer
ISBN: 1493911546
Category: Medical
Page: 584
View: 8819
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A thorough introduction is provided to the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic information as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. The breadth and depth of topics covered make it an essential reference for those new to the field as well more seasoned investigators.

MALDI MS

A Practical Guide to Instrumentation, Methods and Applications
Author: Franz Hillenkamp,Jasna Peter-Katalinic
Publisher: John Wiley & Sons
ISBN: 3527673741
Category: Science
Page: 480
View: 7293
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This authoritative book on MALDI MS, now finally available in its second edition and edited by one of its inventors, gives an in-depth description of the many different applications, along with a detailed discussion of the technology itself. Thoroughly updated and expanded, with contributions from key players in the field, this unique book provides a comprehensive overview of MALDI MS along with its possibilities and limitations. The initial chapters deal with the technology and the instrumental setup, followed by chapters on the use of MALDI MS in protein research (including proteomics), genomics, glycomics and lipidomics. The option of MALDI-MS for the analysis of polymers and small molecules are also covered in separate chapters, while new to this edition is a section devoted to the interplay of MALDI MS and bioinformatics. A much-needed practical and educational asset for individuals, academic institutions and companies in the field of bioanalytics.

Marine Glycobiology

Principles and Applications
Author: Se-Kwon Kim
Publisher: CRC Press
ISBN: 1498709621
Category: Medical
Page: 520
View: 623
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Marine glycobiology is an emerging and exciting area in the field of science and medicine. Glycobiology, the study of the structure and function of carbohydrates and carbohydrate-containing molecules, is fundamental to all biological systems and represents a developing field of science that has made huge advances in the last half-century. This book revolutionizes the concept of marine glycobiology, focusing on the latest principles and applications of marine glycobiology and their relationships.

Ion Mobility Spectrometry - Mass Spectrometry

Theory and Applications
Author: Charles L. Wilkins,Sarah Trimpin
Publisher: CRC Press
ISBN: 9781439813256
Category: House & Home
Page: 374
View: 9486
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The analytical power of ion mobility spectrometry-mass spectrometry (IMS-MS) instruments is poised to advance this technology from research to analytical laboratories. Exploring these developments at this critical juncture, Ion Mobility Spectrometry-Mass Spectrometry: Theory and Applications covers the tools, techniques, and applications involved when molecular size and shape information is combined with the well-known analytical advantages of high-performance mass spectrometry. One of the Most Exciting Developments in Contemporary Mass Spectrometry After presenting an overview chapter and the fundamentals, the book focuses on instrumentation and ionization sources. It describes an ion-mobility-capable quadrupole time-of-flight mass spectrometer, the differential mobility analyzer, a cryogenic-temperature ion mobility mass spectrometer, the atmospheric solids analysis probe method, and laserspray ionization. In the final applications-oriented chapters, the contributors explore how homebuilt and commercial instruments using electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) methods are employed to solve biological and synthetic issues. Harness the Power of IMS-MS for Analyzing Complex Substances This work helps readers unfamiliar with IMS-MS to understand its fundamental theory and practical applications. It also encourages them to investigate the potential analytical uses of IMS-MS and further explore the power of this method. Numerous color figures are included on a CD-ROM.

More Than a Memoir


Author: NELSON J. LEONARD
Publisher: Xlibris Corporation
ISBN: 1469114402
Category: Biography & Autobiography
Page: 431
View: 2517
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In this unusual autobiography you will find the full story of a life spanning much of the twentieth century. Selective reading will disclose How a teacher/scientist may develop The importance of focus and integrity The fascination of doing chemical and biochemical research with students and colleagues The excitement of discovery and of facing new challenges Personal details about family life and friendships Career choices and diversions Plus In the 23 (!) appendices, you will find details concerning Other activities attendant upon a career in science The influence of conferences, symposia, and international scientific connections The coworkers who built the reputation of the author