Ion Channels

From Structure to Function
Author: James N. C. Kew,Ceri H. Davies
Publisher: Oxford University Press, USA
ISBN: 0199296758
Category: Medical
Page: 562
View: 5834
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Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.

Ion Channels

Molecules in Action
Author: David J. Aidley,Peter R. Stanfield
Publisher: Cambridge University Press
ISBN: 9780521498821
Category: Medical
Page: 307
View: 9218
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Ion channels are crucial components of living cells. Situated in the cell membrane, they allow ions to pass from one side of the membrane to the other. This book provides an overview of ion channel study, including up-to-date coverage of the permeability and selectivity of channels, their gating and modulation, their response to drugs and toxins, and the human diseases that result from channel malfunction. Students of molecular biology, biochemistry, physiology, and neurobiology will benefit from this modern, concise text.

Ion Channels and Disease


Author: Frances M. Ashcroft
Publisher: Academic Press
ISBN: 0080535216
Category: Science
Page: 481
View: 2909
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Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype

Cholesterol Regulation of Ion Channels and Receptors


Author: Irena Levitan,Francisco Barrantes
Publisher: John Wiley & Sons
ISBN: 1118342305
Category: Science
Page: 302
View: 6420
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Examines new research on the role of cholesterol inregulating ion channels and receptors and its effect onhealth Drawing together and analyzing all the latest research findings,this book explores the role of cholesterol in the regulation of ionchannels and receptors, including its pathological effects. It isthe first book to comprehensively describe the complex mechanismsby which cholesterol regulates two major classes of membraneproteins. Moreover, it sheds new light on how cholesterol affectsessential cellular functions such as the contraction of the heart,propagation of nerve impulses, and regulation of blood pressure andkidney function. Written and edited by leading pioneers in the field,Cholesterol Regulation of Ion Channels and Receptors isdivided into three parts: Part I, Cholesterol Regulation of Membrane Properties,introduces the heterogeneity of cholesterol distribution inbiological membranes and the physical and biological implicationsof the formation of cholesterol-rich membrane domains. Part II, Cholesterol Regulation of Ion Channels,examines the mechanisms underlying cholesterol sensitivities of ionchannels, including the regulation of ion channels by cholesterolas a boundary lipid. Part III, Cholesterol Regulation of Receptors, exploresthe latest discoveries concerning how cholesterol regulatesdistinct types of receptors, including G-protein coupled receptors,LDL and scavenger receptors, and innate immune systemreceptors. Increased levels of cholesterol represent a major health risk.Understanding cholesterol regulation of ion channels and receptorsis essential for facilitating the development of new therapeuticstrategies to alleviate the impact of pathological cholesterolconditions. With this book as their guide, readers have access tothe most current knowledge in the field.

Handbook of Ion Channels


Author: Jie Zheng,Matthew C. Trudeau
Publisher: CRC Press
ISBN: 1466551429
Category: Medical
Page: 691
View: 9506
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The New Benchmark for Understanding the Latest Developments of Ion Channels Ion channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of cells. In nonexcitable tissues, they also help regulate basic salt balance critical for homeostasis. All of these features make ion channels important targets for pharmaceuticals. Handbook of Ion Channels illustrates the fundamental importance of these membrane proteins to human health and disease. Renowned researchers from around the world introduce the technical aspects of ion channel research, provide a modern guide to the properties of major ion channels, and present powerful methods for modeling ion channel diseases and performing clinical trials for ion channel drugs. Conveniently divided into five parts, the handbook first describes the basic concepts of permeation and gating mechanisms, balancing classic theories and the latest developments. The second part covers the principles and practical issues of both traditional and new ion channel techniques and their applications to channel research. The third part organizes the material to follow the superfamilies of ion channels. This part focuses on the classification, properties, gating mechanisms, function, and pharmacology of established and novel channel types. The fourth part addresses ion channel regulation as well as trafficking and distribution. The final part examines several ion channel-related diseases, discussing genetics, mechanisms, and pharmaceutical advances.

Sensing with Ion Channels


Author: Boris Martinac
Publisher: Springer Science & Business Media
ISBN: 3540727396
Category: Science
Page: 304
View: 4127
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This is the first book that is not exclusively focused on ion channels functioning in sensory mechanisms that are characteristic of animals and humans, but also describes the role of ion channels in signal transduction mechanisms found in microbial cells and plants. It summarizes comprehensively the progress that has been made in studies of ion channels and their role in sensory physiology.

Potassium Ion Channels: Molecular Structure, Function, and Diseases


Author: N.A
Publisher: Academic Press
ISBN: 9780080585178
Category: Science
Page: 492
View: 1057
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This book is the first to focus on potassium ion channels and covers the recent remarkable progress made in research on these proteins. Many diseases are caused by the abnormalities of potassium ion channels. They include diabetes mellitus, life-threatening hereditary cardiac arrhythmia, epilepsy, neural degeneration, and renal hypertension. Written by leading scientists in the field, this volume offers readers a comprehensive update of this field in the understanding of the genes, molecular structure, function and diseases of potassium ion channels. Key Features * The first comprehensive volume on potassium ion channels in all aspects of genes, molecular structure, function, and diseases * Completely up-to-date information * Written by leading scientists in the field

Biological Membrane Ion Channels

Dynamics, Structure, and Applications
Author: Shin-Ho Chung,Olaf S. Anderson,Vikram V. Krishnamurthy
Publisher: Springer Science & Business Media
ISBN: 0387689192
Category: Science
Page: 658
View: 8634
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This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.

Ion Channel Regulation


Author: N.A
Publisher: Academic Press
ISBN: 9780080526454
Category: Science
Page: 318
View: 2086
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Volume 33 reviews the current understanding of ion channel regulation by signal transduction pathways. Ion channels are no longer viewed simply as the voltage-gated resistors of biophysicists or the ligand-gated receptors of biochemists. They have been transformed during the past 20 years into signaling proteins that regulate every aspect of cell physiology. In addition to the voltage-gated channels, which provide the ionic currents to generate and spread neuronal activity, and the calcium ions to trigger synaptic transmission, hormonal secretion, and muscle contraction, new gene families of ion channel proteins regulate cell migration, cell cycle progression, apoptosis, and gene transcription, as well as electrical excitability. Even the genome of the lowly roundworm Caenorhabditis elegans encodes almost 100 distinct genes for potassium-selective channels alone. Most of these new channel proteins are insensitive to membrane potential, yet in humans, mutations in these genes disrupt development and increase individual susceptibility to debilitating and lethal diseases. How do cells regulate the activity of these channels? How might we restore their normal function? In Ion Channel Regulation, many of the experts who pioneered these discoveries provide detailed summaries of our current understanding of the molecular mechanisms that control ion channel activity. Key Features * Reviews brain functioning at the fundamental, molecular level * Describes key systems that control signaling between and within cells * Explains how channels are used to stimulate growth and changes to activity of the nucleus and genome

From Ion Channels to Cell-to-Cell Conversations


Author: Ramón Latorre,Juan Carlos Sáez
Publisher: Springer Science & Business Media
ISBN: 1489917950
Category: Medical
Page: 504
View: 7794
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Ion channels allow us to see nature in all its magnificence, to hear a Bach suite, to smell the aroma of grandmother's cooking, and, in this regard, they put us in contact with the external world. These ion channels are protein molecules located in the cell membrane. In complex organisms, cells need to communicate in order to know about their metabolic status and to act in a coordinate manner. The latter is also accomplished by a class of ion channels able to pierce the lipid bilayer membranes of two adjacent cells. These intercellular channels are the functional subunits of gap junctions. Accordingly, the book is divided in two parts: the first part is dedicated to ion channels that look to the external world, and the second part is dedicated to gap junctions found at cell interfaces. This book is based on a series of symposia for a meeting on ion channels and gap junctions held in Santiago, Chile, on November 28-30, 1995. The book should be useful to graduate students taking the first steps in this field as well as a reference for the aficionado. The aim of the meeting was mainly to show the impact of various modern techniques, including cell biology, molecular biology, biophysics, and molecular genetics techniques in the study of these ubiquitous intrinsic membrane proteins. Molecular-genetics techniques paved the road to the manipulation of the channel forming molecules.

Mechanosensitive Ion Channels


Author: N.A
Publisher: Elsevier
ISBN: 0080494404
Category: Science
Page: 616
View: 4684
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Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids; MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism. Lessons From Polycystin-2 (TRPP2); Lipid Stress at Play: Mechanosensitivity of Voltage-Gated Channels; Hair Cell Mechanotransduction: The Dynamic Interplay between Structure and Function; Pharmacology of Hair Cell MS Channels; Hair Cell Mechanotransduction; Models of Hair Cell Mechanotrasduction; Touch; Mechanosensitive Ion Channels in Dystrophic Muscle; Mechanotransduction in Endothelial Cells; MS Channels in Tumor Cell Migration; Mechanosensitive Channels in Regulating Smooth Muscle Contraction in the GI; Mechanosensitive Ion Channels in Blood-Pressure-Sensing Baroreceptor Neurons.

Ion channels


Author: Toshio Narahashi
Publisher: Plenum Publishing Corporation
ISBN: N.A
Category: Medical
Page: 348
View: 1818
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Ion Channels in Health and Disease


Author: Geoffrey S. Pitt
Publisher: Academic Press
ISBN: 0128020172
Category: Science
Page: 392
View: 8681
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Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research. Provides an overview of fundamental concepts in ion channels research to link defects in human disease Written in an accessible manner, without jargon Provides a helpful, easy cross-reference for diseases, channels, and tissues

Ion Channels and Genetic Diseases


Author: David C. Dawson,Raymond A. Frizzell
Publisher: Rockefeller Univ. Press
ISBN: N.A
Category: Genetic disorders
Page: 178
View: 7485
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Pumps, Transporters, and Ion Channels


Author: Francisco Sepulveda,Francisco Bezanilla
Publisher: Springer Science & Business Media
ISBN: 0387274243
Category: Science
Page: 165
View: 621
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Second author, Francisco Benzanilla, is with the Univ. of California, Los Angeles. Presents the proceedings of a symposium on Pumps, Transporters, and Ion Channels: Studies on Their Structure, Function, and Cell Biology, held in Valdivia, Chile in December, 2001.

Ion Channels


Author: Bernard Fermini,Birgit Priest
Publisher: Springer Science & Business Media
ISBN: 3540797297
Category: Science
Page: 171
View: 6713
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Ion channels play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes. Because of their prevalence and the critical role they play in virtually all tissue types and organs, ion channels are also involved in a number of pathophysiological conditions. The aim of this volume is to review recent advances in the field of ion channel related diseases. Following an overview chapter summarizing the current state of ion channel screening technologies, five topics covering areas such as cancer, cardiac arrhythmias, cystic fibrosis, and pain have been selected, and the current state of knowledge is presented by leading experts in their field. Each chapter is structured to cover the biological rationale for the target, the current status in the development of agents to treat the disease, and future prospects and challenges facing each therapeutic area. The reader will receive a critical overview covering the progress made in the rapidly developing and complex field of ion channels and diseases.

Ion Channels


Author: Bernardo Rudy,Linda E. Iverson
Publisher: Gulf Professional Publishing
ISBN: 9780126016956
Category: Science
Page: 917
View: 1462
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This is an unabridged, comb bound version of Ion Channels: Volume 207 of Methods of Enzymology. Techniques for the electrophysiological recording of ion channels in a number of different cell types, including microorganisms, are described in this volume. Key Features * Applications of electrophysiological techniques * Expression in heterologous systems * Reconstitution of lipid bilayers * Purification and characterization of ion channel proteins and genes * Recording of ion channels of intracellular membranes and microorganisms * Data storage and analysis

Ion Channel Factsbook

Voltage-Gated Channels
Author: William J. Brammar
Publisher: Academic Press
ISBN: 9780080535203
Category: Science
Page: 860
View: 4438
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The Academic Press FactsBooks series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as 'a growing series of excellent manuals' by Molecular Medicine Today, and 'essential works of reference' by Trends in Biochemical Sciences, the FactsBooks have become the most popular comprehensive data resources available. As they are meticulously researched and use an easy-to-follow format, the FactsBooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity. In a set of four interrelated volumes, The Ion Channel FactsBook provides a comprehensive framework of facts about channel molecules central to electrical signaling phenomena in living cells. The fourth volume is devoted to Voltage-gated Channel Families, including those molecular complexes activated or modulated by calcium, potassium, and chloride. Nomenclature Expression Sequence Analyses Structure and function Electrophysiology Pharmacology Information retrieval

Ion Channel Pharmacology


Author: Bernat Soria,Valent?n Ce?a
Publisher: Oxford University Press, USA
ISBN: 9780198523604
Category: Medical
Page: 473
View: 4539
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Molecular biology techniques have led to increased understanding of ion channel structure which has opened the way for the development of new drugs targeted at specific types of ion channels. This book aims to provide a fully comprehensive, single-volume overview of the effects of different drugs and toxins on ionic channels, with every chapter providing a detailed description of the pharmacology of each particular ion channel. It will be an essential reference tool for all researchers inthis topical and fast-moving subject area.

Mechanosensitive Ion Channels


Author: Andre Kamkin,Irina Kiseleva
Publisher: Springer Science & Business Media
ISBN: 1402064268
Category: Science
Page: 382
View: 379
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This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and signaling cascades research. Key problems of cell mechanobiology are also discussed. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.