Neuroanatomy and Pathology of Sporadic Parkinson's Disease


Author: Heiko Braak,Kelly Del Tredici
Publisher: Springer Science & Business Media
ISBN: 3540798501
Category: Medical
Page: 119
View: 2220
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The synucleinopathy sporadic Parkinson’s disease (sPD) is the second most frequent degenerative disorder of the human nervous system after Alzheimer’s disease. The propensity for developing sPD exists in all ethnic groups worldwide, and the prevalence of the disorder increases considerably with age, thereby imposing an enormous social and economic burden on societies with increased life expectancy. The sPD-associated pathological process is progressive, does not go into remission, and can take decades to reach its culmination if it is not be terminated prematurely by death owing to other causes. Against the background of the normal morphology and anatomy, the authors analyze the pathoanatomy of sPD in the nervous system at various neuropathological stages and summarize the potential functional consequences of the lesions.

Nonmotor Parkinson's: The Hidden Face

Management and the Hidden Face of Related Disorders
Author: N.A
Publisher: Academic Press
ISBN: 0128126043
Category: Science
Page: 764
View: 8264
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Non-motor Parkinson's: The Hidden Face-Management and the Hidden Face of Related Disorders, Volume 134, the latest release in the International Review of Neurobiology series, is an up-to-date and comprehensive textbook addressing non-motor aspects of Parkinson’s disease, a key unmet need. Specific chapters in this updated release include Therapeutics and NMS in PD, Non-motor effects of conventional and transdermal therapies in PD, Infusion therapy, CDD and NMS in PD, DBS and NMS in PD, TMS and implications for NMS in PD, Botulinum toxin therapy and NMS in PD, and Nutrition and NMS in PD, amongst others. Including practical tips for non-specialists and clinical algorithms, the book contains contributions from over 40 opinion leaders in the field of movement disorders. It provides practitioners and researchers with a laboratory, to bedside, to caregiver perspective. Presents a comprehensive textbook on the non motor aspects of Parkinson’s disease Includes practical tips and clinical algorithms, and is the only textbook to bring a holistic approach Contains contributions from over 40 global opinion leaders in the field of movement disorders Provides special chapters on exercise, personalized medicine, osteoporosis, genetics, treatment aspects and nutrition

The Realisation of Concepts

Infinity, Cognition, and Health
Author: W.M. Bernstein
Publisher: Routledge
ISBN: 0429922000
Category: Psychology
Page: 250
View: 8144
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There has recently been a flurry of theoretical activity in affective neuroscience and neuropsychoanalysis. This book argues that the ability to integrate biological and psychological levels of understanding is inhibited by two important issues. First is the assumption made by most theorists that physical and mental phenomena are essentially different ("the Hard Problem"). Second, is the ambiguity of the widely used "Affect Concept". Ideas about the autonomic nervous system are integrated with those from the author's previous text A Basic Theory of Neuropsychoanalysis. The Realization of Concepts is based on four key assumptions: (1) There is no "Hard Problem"; (2) Motivational theory and cognitive theory can be integrated to create more valid models of body, brain and mind interactions; (3) "Affect Concepts" are superfluous and work to inhibit theory integration; and, (4) Affect theory developed as a "compromise formation" in response to radical reductionism. Dynamic parasympathetic braking processes are seen as centrally important causes of competence to use semantic self and nonself-concepts to regulate sensory data, feelings, other concepts, and overt behaviour. A model is presented which describes how levels of sympathetic arousal and parasympathetic tone interact to cause normal, pathological and highly competent brain and mind states. Combining talk therapies with real time biofeedback data is described as a method for enhancing the parasympathetic tone.

Encyclopedia of Movement Disorders


Author: N.A
Publisher: Academic Press
ISBN: 012374105X
Category: Science
Page: 1632
View: 705
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The Encyclopedia of Movement Disorders is a comprehensive reference work on movement disorders, encompassing a wide variety of topics in neurology, neurosurgery, psychiatry and pharmacology. This compilation will feature more than 300 focused entries, including sections on different disease states, pathophysiology, epidemiology, genetics, clinical presentation, diagnostic tools, as well as discussions on relevant basic science topics. This Encyclopedia is an essential addition to any collection, written to be accessible for both the clinical and non-clinical reader. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in the laboratory to the clinical features, pathophysiology and treatment of movement disorders. The Encyclopedia targets a broad readership, ranging from students to general physicians, basic scientists and Movement Disorder specialists. Published both in print and via Elsevier’s online platform of Science Direct, this Encyclopedia will have the enhanced option of integrating traditional print with online multimedia. Connects experimental findings made in the laboratory to the clinical features, pathophysiology, and treatment of movement disorders Encompasses a wide variety of topics in neurology neurosurgery, psychiatry, and pharmacology Written for a broad readership ranging from students to general physicians, basic scientists, and movement disorder specialists

Neuroanatomy and Pathology of Sporadic Alzheimer's Disease


Author: Heiko Braak,Kelly Del Tredici
Publisher: Springer
ISBN: 3319126792
Category: Medical
Page: 162
View: 5129
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As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail

Development of the Cerebellum from Molecular Aspects to Diseases


Author: Hassan Marzban
Publisher: Springer
ISBN: 3319597493
Category: Medical
Page: 504
View: 9571
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The authors present the most current and cutting-edge knowledge regarding the molecular basis of cerebellar development, focusing on information relevant to laboratory scientists and clinicians providing service to patients with cerebellar disorders. Knowledge obtained from advanced neuroimaging techniques that are used during development, and from molecular- and genetic-based studies has provided rapidly-growing evidence that the cerebellum is a brain region that is highly impacted by developmental defects. Cerebellar defects result in significant intellectual and motor function impairment that affects both the patients and their families.

The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy


Author: Udo Rüb,Jean Paul G. Vonsattel,Helmut Heinsen,Horst-Werner Korf
Publisher: Springer
ISBN: 331919285X
Category: Medical
Page: 146
View: 538
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This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.

Genomic Elements in Health, Disease and Evolution

Junk DNA
Author: Kyriacos Felekkis,Konstantinos Voskarides
Publisher: Springer
ISBN: 1493930702
Category: Medical
Page: 315
View: 641
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Over 98% of the human genome contains non-coding DNA sequences. For many years molecular biologists referred to this component of the genome as the “junk” DNA since it does not code for any “useful” protein product. Over the last years this notion changed significantly as scientists discovered that a large part of this DNA contains various genomic elements that have important roles in cell physiology. Genomic elements such as non-coding RNAs, transposons, splicing RNAs, DNA repeats and others were shown to play a significant role in regulating gene expression. In addition, all these elements were implicated to contribute in the pathogenesis or progression of various human diseases. In this book, the editor will attempt to describe all these genomic elements that constitute the junk DNA of the genome. For every genomic element, the physiologic role in the organism, its role in evolution and any possible involvement in human diseases will be discussed. Additionally, interaction between these elements in normal or pathologic condition will be discussed. Since a large amount of new knowledge is generated daily in regards to these genomic elements, this book will attempt to combine all the information in a single publication that can serve as a reference for future studies. The first part will discuss RNA elements such as microRNAs, long non-coding RNAs, piRNAs and splicing RNAs. The second part of the book will deal with transposons, retrotransposons and DNA transposons. Finally the third part of the book will discuss DNA elements that include DNA repeats, conserved non-coding sequences, distal genomic elements, introns, pseudogenes, CpG islands and telomeres. For miRNAs and CNVs a separate chapter will be dedicated to their role in human diseases since an extensive amount of information exists about these two elements.

DeGowin's Diagnostic Examination, Tenth Edition


Author: Richard LeBlond,Donald Brown,Richard DeGowin
Publisher: McGraw Hill Professional
ISBN: 0071814485
Category: Medical
Page: 896
View: 765
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For more than forty years, the single-best guide for learning how to become a master clinical diagnostician Much more than a text describing how to perform a history and physical examination, DeGowin's Diagnostic Examination is unmatched in its ability to help you logically assess symptoms and physical signs to facilitate development of reasonable, testable diagnostic hypotheses. Part physical examination primer, part differential diagnosis guide, DeGowin's: Describes how to obtain a complete history and perform a thorough physical examination Links symptoms and signs with the pathophysiology of disease Presents a symptom, sign, anatomy, and physiology-based approach to differential diagnosis Facilitates efficient cost-effective diagnostic testing using focused differential diagnoses Organized as a practical bedside guide to assist diagnosis, DeGowin's is valuable as a quick reference at the point-of-care or as a text to study the principles and practice of history taking and physical examination.

The Ultimate Guide to Choosing a Medical Specialty, Third Edition


Author: Brian Freeman
Publisher: McGraw Hill Professional
ISBN: 0071790284
Category: Medical
Page: 504
View: 8006
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You owe it to yourself to read this book before you choose a medical specialty! The Ultimate Guide to Choosing a Medical Specialty, 3rd edition delivers a well-researched, insider’s look at the complex issues medical students face when choosing a medical specialty. Supported by first-hand knowledge, useful facts and statistics – plus the author’s personal experience and gut-level reports from current residents -- this unique guide provides everything necessary to compare specialties and make a confident decision. The Ultimate Guide to Choosing a Medical Specialty, 3rd edition is divided into two sections: Part 1 Planning Your Medical Career delves into the main issues surrounding the choice of your medical specialty. These twelve chapters provide everything you need to begin making this major decision – from how to research each specialty to how to apply for residency. Part 2 Specialty Profiles features chapters devoted to each of the 20 major specialties. It provides important information such as the latest salary information, employment data, and match statistics. Features: An “insider’s look” at different areas of medicine -- with specialty chapters written by physicians just out of residency training Candid and revealing descriptions of each specialty Profiles of the major specialties, including those to which you may have had little exposure, such as radiation oncology A concise, up-to-date guide to the residency application and matching process A chapter with valuable advice to help you maximize your success in obtaining a residency position in each field Updated to include alternative career paths for MDs, such as laboratory science, the military, MD/MBA, and MD/JD

Encyclopedia of the Neurological Sciences


Author: Michael Jeffrey Aminoff,Robert B. Daroff
Publisher: N.A
ISBN: 9780122268700
Category: Medical
Page: 4300
View: 4117
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This major reference work embraces all aspects of neurology: the disorders, the underlying neurobiology, methods and history. The four volume set is arranged for ease of use.

Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease


Author: Hoa Huu Phuc Nguyen,M. Angela Cenci
Publisher: Springer
ISBN: 366246344X
Category: Medical
Page: 397
View: 854
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Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.

Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease


Author: Lori M. Buhlman
Publisher: Springer
ISBN: 3319421395
Category: Medical
Page: 275
View: 5796
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This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.

Cellular and Molecular Control of Neuronal Migration


Author: Laurent Nguyen,Simon Hippenmeyer
Publisher: Springer Science & Business Media
ISBN: 940077687X
Category: Medical
Page: 186
View: 7651
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Cellular and Molecular Control of Neuronal Migration provides an up-to-date collection of reviews on the molecular and cellular principles of neuronal migration in the mammalian brain. Over the last decades a rich catalogue of signaling molecules controlling neuronal migration has been compiled, and within this book an international panel of experts provides up-to-date discussions of the state of knowledge how these distinct signaling pathways regulate various aspects of neuronal migration. This book introduces the reader to the latest discoveries and concepts of neuronal migration enabled through the application of most sophisticated methods and cutting edge experimental approaches. Cellular and Molecular Control of Neuronal Migration also provides an update on the underlying cellular and molecular basis of neurodevelopmental migration disorders in human patients for all interested neuroscientists and clinicians.

Progress in Motor Control

Theories and Translations
Author: Jozsef Laczko,Mark L. Latash
Publisher: Springer
ISBN: 3319473131
Category: Medical
Page: 388
View: 6241
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This single volume brings together both theoretical developments in the field of motor control and their translation into such fields as movement disorders, motor rehabilitation, robotics, prosthetics, brain-machine interface, and skill learning. Motor control has established itself as an area of scientific research characterized by a multi-disciplinary approach. Its goal is to promote cooperation and mutual understanding among researchers addressing different aspects of the complex phenomenon of motor coordination. Topics covered include recent theoretical advances from various fields, the neurophysiology of complex natural movements, the equilibrium-point hypothesis, motor learning of skilled behaviors, the effects of age, brain injury, or systemic disorders such as Parkinson's Disease, and brain-computer interfaces. The chapter ‘Encoding Temporal Features of Skilled Movements—What, Whether and How?’ is available open access under a CC BY 4.0 license via link.springer.com.

An Essay on the Shaking Palsy


Author: James Parkinson
Publisher: N.A
ISBN: N.A
Category: Clinical medicine
Page: 66
View: 2853
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The Fractal Geometry of the Brain


Author: Antonio Di Ieva
Publisher: Springer
ISBN: 1493939955
Category: Medical
Page: 585
View: 3861
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Reviews the most intriguing applications of fractal analysis in neuroscience with a focus on current and future potential, limits, advantages, and disadvantages. Will bring an understanding of fractals to clinicians and researchers also if they do not have a mathematical background, and will serve as a good tool for teaching the translational applications of computational models to students and scholars of different disciplines. This comprehensive collection is organized in four parts: (1) Basics of fractal analysis; (2) Applications of fractals to the basic neurosciences; (3) Applications of fractals to the clinical neurosciences; (4) Analysis software, modeling and methodology.

Bioinformatics for Geneticists

A Bioinformatics Primer for the Analysis of Genetic Data
Author: Michael R. Barnes
Publisher: John Wiley & Sons
ISBN: 0470026197
Category: Computers
Page: 554
View: 4790
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Bioinformatics for geneticists describes the key bioinformatics and genetic analysis processes that are needed to identify human genetic determinants. Including SNP functional analysis and statistical genetics.

Visual Development


Author: Nigel W. Daw
Publisher: Springer Science & Business Media
ISBN: 1461490596
Category: Medical
Page: 245
View: 6895
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The only book on the market to cover the psychophysics, anatomy, physiology, and clinical deficits of the developing visual system in an accessible format and length. The visual system is the most commonly studied aspect of the nervous system and is the primary model for the study of both normal development and the effects of environment and sensory deprivation on development. This third edition highlights new research and features a large number of illustrations, many in color. It can be used as a supplementary text in neuroscience and ophthalmology courses. This book is a great resource for both novice and advanced researchers in the field of vision.

Principles of Molecular Neurosurgery


Author: Andrew Freese
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805577842
Category: Medical
Page: 659
View: 3729
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The future of neurosurgery will be characterized by less invasive, molecular technologies that promise to revolutionize the field of neurosurgery and impact the treatment of additional neurological disorders, including neurometabolic diseases, stroke, dementias, affective and psychiatric diseases, movement disorders, epilepsy, and others. This book encompasses developing an understanding of the principles underlying the advent of novel molecular approaches to neurological and neurosurgical diseases. It Identifies key principles that will allow dramatic improvement in the treatment and outcomes of patients suffering from a varity of disorders affecting the central nervous system and spinal axis. This volume gives neurosurgeons an excellent understanding of the development of novel molecular and cellular technologies that will markedly change the way neurosurgery is practiced in the near future. It is also of special interest to neurologists, psychiatrists, physiatrists, spinal orthopaedic surgeons, neurobiologists and gene therapy research scientists.