Physicochemical Basis of Pharmaceuticals


Author: Humphrey Moynihan,Abina Crean
Publisher: Oxford University Press
ISBN: 0199232849
Category: Business & Economics
Page: 296
View: 8975
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The Physicochemical Basis of Pharmaceuticals explores the physical and chemical phenomena which affect the formulation and bio-availability of drug substances to give a straightforward, accessible treatment of the essential concepts affecting the absorption and distribution of drugs.

Pharmaceutics

The Science of Medicine Design
Author: Philip Denton,Chris Rostron
Publisher: Oxford University Press
ISBN: 0199655316
Category: Medical
Page: 273
View: 3295
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Taking medication is a common occurrence for many people, whether it is to soothe an aching head, regulate blood sugars, or to treat life threatening conditions, such as HIV or cancer. In the UK alone, over 900 million prescriptions are dispensed every year. Overseeing all of this are pharmacists: experts in medicines and their use. The Integrated Foundations of Pharmacy series supports those who are at the beginning of their journey to become a pharmacist. The reader will begin to understand how a drug molecule is made; the process that turns it into a medicine; the role the pharmacist has when dispensing that medicine; and what happens in the body when it is taken. Most importantly, the series shows how each of these aspects are integrated, reflecting the most up-to-date teaching practices. Pharmaceutics: the science of medicine design explores the different forms that medicines can take, and demonstrates how being able to select the best form - be it a tablet, injectable liquid, or an inhaled gas - requires an understanding of how chemicals behave in different physical states. Online Resource Centre The Online Resource Centre to accompany Pharmaceutics: the science of medicine design features: For registered adopters of the book: - Figures from the book, available to download. For students: - Self-assessment questions to help the reader to check and reinforce understanding of the material introduced in each chapter.

Physicochemical Principles of Pharmacy


Author: A. T. Florence,D. Attwood
Publisher: Macmillan International Higher Education
ISBN: 1349144169
Category: Medicine
Page: 564
View: 481
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Florence and Attwood's well known textbook uses pharmaceutical examples to illustrate the underlying physical chemistry of drug characterisation, formulation, delivery, transport and adsorption. Students of pharmacology, toxicology, medicine and researchers will want this book.

Colloid and Interface Science in Pharmaceutical Research and Development


Author: Hiroyuki Ohshima,Kimiko Makino
Publisher: Elsevier
ISBN: 0444626085
Category: Technology & Engineering
Page: 532
View: 8048
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Colloid and Interface Science in Pharmaceutical Research and Development describes the role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed account of colloid theory, and explains physicochemical properties of the colloidal-pharmaceutical systems, and the methods for their measurement. The book starts with fundamentals in Part I, covering fundamental aspects of colloid and interface sciences as applied to pharmaceutical sciences and thus should be suitable for teaching. Parts II and III treat applications and measurements, and they explains the application of these properties and their influence and use for the development of new drugs. Provides a clear description of the fundamentals of colloid and interface science relevant to drug research and development Explains the physicochemical/colloidal basis of pharmaceutical science Lists modern experimental characterization techniques, provides analytical equations and explanations on analyzing the experimental data Describes the most advanced techniques, AFM (Atomic Force Microscopy), SFA (Surface Force Apparatus) in detail

Essentials of Pharmaceutical Chemistry


Author: Donald Cairns
Publisher: Pharmaceutical Press
ISBN: 0853699798
Category: Medical
Page: 308
View: 9717
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An introduction to pharmaceutical chemistry for undergraduate pharmacy, chemistry and medicinal chemistry students. Essentials of Pharmaceutical Chemistry is a chemistry introduction that covers all of the core material necessary to provide an understanding of the basic chemistry of drug molecules. Now a core text on many university courses, it contains numerous worked examples and problems. The 4th edition includes new chapters on Chromatographic Methods of Analysis, and Medicinal Chemistry - The Science of Drug Design.

Handbook of Pharmaceutical Granulation Technology, Third Edition


Author: Dilip M. Parikh
Publisher: CRC Press
ISBN: 1616310030
Category: Medical
Page: 676
View: 4969
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The Third Edition presents all pharmaceutical industry personnel and those in academia with critical updates on the recent advances in granulation technology and changes in FDA regulatory guidelines. Addressing precisely how these recent innovations and revisions affect unit operation of particle generation and granulation, this text assists the reader in selecting the ideal technology for his/her company’s particular drug delivery system. This knowledge helps ensure that regulatory guidelines are followed and met in a cost-effective manner. Here are just a few of the new topics discussed in this revised and expanded handbook: spray drying nanotechnology biotechnologically derived drugs nutraceuticals controlled release drugs particle engineering supercritical fluids concepts of design space process optimization regulation harmonization by global health authorities process controlexpert systems Process Analytical Technology (PAT) regulatory issues in granulation In addition, all chapters in the Handbook of Pharmaceutical Granulation Technology explore the fundamentals of powder characterization, granulation, and state-of-the-art technologies, modeling, application of expert systems, and manufacturing optimization.

The Quality Control of Medicines

Proceedings of the 35th International Congress of Pharmaceutical Sciences, Dublin, 1975
Author: P.B. Deasy,R.F. Timoney
Publisher: Elsevier
ISBN: 1483165027
Category: Medical
Page: 412
View: 3102
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The Quality Control of Medicines documents the proceedings of the 35th International Congress of Pharmaceutical Sciences, organized by the Pharmaceutical Society of Ireland on behalf of the Federation Internationale Pharmaceutique, held in Dublin, on 1-5 September 1975. The theme chosen for the Congress was ""the basis for the quality control of medicines"", because of the importance and relevance of quality control in the production and distribution of medicines at national and international levels. This volume is arranged according to the manner in which the theme of the Congress was developed by the eminent invited speakers. Following the inaugural address a main symposium was held where five speakers presented a review of the quality control of medicines under the general headings of (i) chemical and physical aspects; (ii) biological aspects; (iii) control of drug delivery systems; (iv) storage problems; and (v) problems of international control. Certain aspects of the content of the main symposium were then developed in greater depth in parallel symposia. In the first parallel symposium some novel physicochemical aspects of the quality control of medicines were treated under the headings of spectrofluorimetry, mass spectrometry, detection in gas chromatography, and automation in pharmaceutical analysis. The second parallel symposium developed certain microbiological aspects of quality control under the headings of sterility testing and microbiological control of non-sterile products and ophthalmic preparations. The final symposium on submissions to regulatory bodies and international aspects of drug control covered aspects of politics in submissions, regulatory problems in small countries, and various pharmacopoeial problems.

The hERG Cardiac Potassium Channel

Structure, Function and Long QT Syndrome
Author: Novartis Foundation
Publisher: John Wiley & Sons
ISBN: 0470021411
Category: Science
Page: 308
View: 7256
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This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding. It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.

The British National Bibliography


Author: Arthur James Wells
Publisher: N.A
ISBN: N.A
Category: English literature
Page: N.A
View: 6329
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Chemical Engineering in the Pharmaceutical Industry

R&D to Manufacturing
Author: David J. am Ende
Publisher: John Wiley & Sons
ISBN: 1118088107
Category: Technology & Engineering
Page: 904
View: 7727
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This book deals with various unique elements in the drug development process within chemical engineering science and pharmaceutical R&D. The book is intended to be used as a professional reference and potentially as a text book reference in pharmaceutical engineering and pharmaceutical sciences. Many of the experimental methods related to pharmaceutical process development are learned on the job. This book is intended to provide many of those important concepts that R&D Engineers and manufacturing Engineers should know and be familiar if they are going to be successful in the Pharmaceutical Industry. These include basic analytics for quantitation of reaction components– often skipped in ChE Reaction Engineering and kinetics books. In addition Chemical Engineering in the Pharmaceutical Industry introduces contemporary methods of data analysis for kinetic modeling and extends these concepts into Quality by Design strategies for regulatory filings. For the current professionals, in-silico process modeling tools that streamline experimental screening approaches is also new and presented here. Continuous flow processing, although mainstream for ChE, is unique in this context given the range of scales and the complex economics associated with transforming existing batch-plant capacity. The book will be split into four distinct yet related parts. These parts will address the fundamentals of analytical techniques for engineers, thermodynamic modeling, and finally provides an appendix with common engineering tools and examples of their applications.

Essentials of Pharmaceutical Preformulation


Author: Simon Gaisford,Mark Saunders
Publisher: John Wiley & Sons
ISBN: 1118423240
Category: Science
Page: 272
View: 7698
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Essentials of Pharmaceutical Preformulation is a study guide which describes the basic principles of pharmaceutical physicochemical characterisation. Successful preformulation requires knowledge of fundamental molecular concepts (solubility, ionisation, partitioning, hygroscopicity and stability) and macroscopic properties (physical form, such as the crystalline and amorphous states, hydrates, solvates and co-crystals and powder properties), familiarity with the techniques used to measure them and appreciation of their effect on product performance, recognising that often there is a position of compromise to be reached between product stability and bioavailability. This text introduces the basic concepts and discusses their wider implication for pharmaceutical development, with reference to many case examples of current drugs and drug products. Special attention is given to the principles and best-practice of the analytical techniques that underpin preformulation (UV spectrophotometry, TLC, DSC, XRPD and HPLC). The material is presented in the typical order that would be followed when developing a medicine and maps onto the indicative pharmacy syllabus of the Royal Pharmaceutical Society of Great Britain Undergraduate-level pharmacy students and R&D / analytical scientists working in the pharmaceutical sector (with or without a pharmaceutical background) will find this text easy to follow with relevant pharmaceutical examples. Essential study guide for pharmacy and pharmaceutical science students Covers the pharmaceutical preformulation components of the Royal Pharmaceutical Society of Great Britain’s indicative syllabus Easy to follow text highlighted with relevant pharmaceutical examples Self-assessment assignments in a variety of formats Written by authors with both academic and industrial experience Companion website with further information to maximise learning

Handbook of Bioequivalence Testing, Second Edition


Author: Sarfaraz K. Niazi
Publisher: CRC Press
ISBN: 1482226383
Category: Medical
Page: 1007
View: 7685
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As the generic pharmaceutical industry continues to grow and thrive, so does the need to conduct adequate, efficient bioequivalence studies. In recent years, there have been significant changes to the statistical models for evaluating bioequivalence. In addition, advances in the analytical technology used to detect drug and metabolite levels have made bioequivalence testing more complex. The second edition of Handbook of Bioequivalence Testing has been completely updated to include the most current information available, including new findings in drug delivery and dosage form design and revised worldwide regulatory requirements. New topics include: A historical perspective on generic pharmaceuticals New guidelines governing submissions related to bioequivalency studies, along with therapeutic code classifications Models of noninferiority Biosimilarity of large molecule drugs Bioequivalence of complementary and alternate medicines Bioequivalence of biosimilar therapeutic proteins and monoclonal antibodies New FDA guidelines for bioanalytical method validation Outsourcing and monitoring of bioequivalence studies The cost of generic drugs is rising much faster than in the past, partly because of the increased costs required for approval—including those for bioequivalence testing. There is a dire need to re-examine the science behind this type of testing to reduce the burden of development costs—allowing companies to develop generic drugs faster and at a lower expense. The final chapter explores the future of bioequivalence testing and proposes radical changes in the process of biowaivers. It suggests how the cost of demonstrating bioequivalence can be reduced through intensive analytical investigation and proposes that regulatory agencies reduce the need for bioequivalence studies in humans. Backed by science and updated with the latest research, this book is destined to spark continued debate on the efficacy of the current bioequivalence testing paradigm.

Transport Processes in Pharmaceutical Systems


Author: Gordon L. Amidon,Ping I. Lee,Elizabeth M. Topp
Publisher: CRC Press
ISBN: 0824746325
Category: Science
Page: 748
View: 1731
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This cutting-edge reference clearly explains pharmaceutical transport phenomena, demonstrating applications ranging from drug or nutrient uptake into vesicle or cell suspensions, drug dissolution and absorption across biological membranes, whole body kinetics, and drug release from polymer reservoirs and matrices to heat and mass transport in freeze-drying and hygroscopicity. Focuses on practical applications of drug delivery from a physical and mechanistic perspective, highlighting biological systems. Written by more than 30 international authorities in the field, Transport Processes in Pharmaceutical Systems discusses the crucial relationship between the transport process and thermodynamic factors analyzes the dynamics of diffusion at liquid-liquid, liquid-solid, and liquid-cultured cell interfaces covers prodrug design for improving membrane transport addresses the effects of external stimuli in altering some natural and synthetic polymer matrices examines properties of hydrogels, including synthesis, swelling degree, swelling kinetics, permeability, biocompatibility, and biodegradability presents mass transfer of drugs and pharmacokinetics based on mass balance descriptions and more! Containing over 1000 references and more than 1100 equations, drawings, photographs, micrographs, and tables, Transport Processes in Pharmaceutical Systems is a must-read resource for research pharmacists, pharmaceutical scientists and chemists, chemical engineers, physical chemists, and upper-level undergraduate and graduate students in these disciplines.

Anorganische Chemie


Author: Duward F. Shriver,Peter W. Atkins,Cooper H. Langford
Publisher: John Wiley & Sons
ISBN: 9783527292509
Category: Science
Page: 909
View: 8358
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Liquid Interfaces In Chemical, Biological And Pharmaceutical Applications


Author: Alexander G. Volkov
Publisher: CRC Press
ISBN: 0824745191
Category: Science
Page: 872
View: 6660
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Providing a comprehensive treatment of surface chemistry and its applications to chemical engineering, biology and medicine, this volume focuses upon the chemical and physical structure of oil-water interfaces and membrane surfaces.

Drug Design


Author: BAREHAM J
Publisher: Academic Press
ISBN: 1483294838
Category: Medical
Page: 374
View: 357
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Drug Design, Volume IX examines various aspects of drug design and covers topics ranging from the consequences of the Hansch paradigm for the pharmaceutical industry to the Masca model of pharmacochemistry. A physicochemical basis for the design of orally active prodrugs is also considered, along with the use of interactive graphics in medicinal chemistry. Comprised of seven chapters, this volume begins with a discussion on efforts to avoid toxicity, not only of drugs, pesticides, and food additives but also of chemicals in general. The reader is then introduced to various aspects of the development of bioactive agents, including the optimization of existing agents by the design of more efficient prodrugs. Other chapters focus on Hansch's paradigm and its application to industrial practice; the application of multivariate statistics to pharmacochemistry; a logico-structural approach to computer-assisted drug design; and spatial arrangements in bioactive molecules. This book will be of interest to pharmacologists, chemists, and those involved in drug design.

Synopsis of Pathophysiology in Nuclear Medicine


Author: Abdelhamid H. Elgazzar
Publisher: Springer
ISBN: 3319034588
Category: Medical
Page: 357
View: 9454
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This Synopsis of Nuclear Medicine Pathophysiology arose from the recognition that there is a need for a compact, readable account of this complex and important subject. The book concisely describes relevant anatomic and physiologic considerations for each organ system and the pathophysiologic features of different relevant diseases and relates them to the scintigraphy of each system. It thereby provides an informative synopsis of the pathophysiologic basis of nuclear medicine and molecular imaging. The volume will serve as a quick reference that will help the reader to understand different diagnostic scintigraphic patterns and to select appropriate treatment modalities based on functional imaging. It will prove useful to undergraduates and postgraduates as well as to practitioners in clinical and research fields.

Towards Better Safety of Drugs and Pharmaceutical Products

Proceedings of the 39th International Congress of Pharmaceutical Sciences of F.I.P., Held in Brighton, U.K., September 3-7, 1979
Author: Douwe D. Breimer
Publisher: Elsevier-North-Holland Biomedical Press
ISBN: N.A
Category: Drugs
Page: 323
View: 3160
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Pharmaceuticals in the Environment

Sources, Fate, Effects and Risks
Author: Klaus Kümmerer
Publisher: Springer Science & Business Media
ISBN: 366209259X
Category: Science
Page: 527
View: 3074
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Following the success of the first edition, this pioneering study of pharmaceuticals in the environment has been updated and greatly extended. It includes the status of research on pharmaceuticals in soil, with attention to terrestrial and aquatic environments as well as new substance categories such as tetracylines and chinolones and the latest results concerning contamination of the environment and risk reduction.

Amorphous Food and Pharmaceutical Systems


Author: Harry Levine
Publisher: Royal Society of Chemistry
ISBN: 9780854048663
Category: Medical
Page: 351
View: 4191
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During the past decade, the importance of amorphous water-soluble substances has been increasingly recognised within the food and pharmaceutical industries. In response, Amorphous Food and Pharmaceutical Systems brings together current leading experts to contribute to this unique cross-disciplinary account of the subject. Coverage includes: water-compatible amorphous solids (physical, chemical behaviour), low water content systems (water as plasticizer); applications in food and pharmaceutical sciences and industries (processing and stability) along with state-of-the-art technology in food and pharmaceutical systems. This timely publication will be welcomed by academic and industrial researchers and professionals in the pharmaceuticals, food, materials and polymer sciences.