The Practice of Medicinal Chemistry


Author: Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan
Publisher: Elsevier
ISBN: 012417213X
Category: Science
Page: 902
View: 3357
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The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

The Practice of Medicinal Chemistry


Author: C. G. Wermuth
Publisher: Elsevier
ISBN: 0127444815
Category: Medical
Page: 768
View: 2942
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Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists with little or no background in medicinal chemistry. These chemists must acquire a good knowledge of medicinal chemistry during their first years in the pharmaceutical/drug discovery industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. The book reviews practical aspects of Medicinal Chemistry, emphasising the daily problems met by the medicinal chemist when dealing with lead discovery/identification methodologies, with structure-activity relationship studies aimed to scale up potency and target selectivity, and when optimising pharmacokinetic and pharmaceutical properties by means of ultimate chemical modifications. This is the second edition of The Practice of Medicinal Chemistry, the first edition being published in February 1996. The new edition is thoroughly revised, with around 30% new material, and refocussed to reflect the recent developments in genomics, proteomics, high throughput screening of compounds and drug solubilisation. An effort has been made to remove the overlap that exists in the previous edition and four new chapters have been introduced. * Written by experts in the field * The first edition of The Practice of Medicinal Chemistry, published in 1996, was nicknamed 'The Bible' by medicinal chemists. * The only available book dealing with the practical aspects of medicinal chemistry, from conception of the molecules through to the production of drugs * An essential practical handbook for the medicinal chemist, working in the pharmaceutical industry, with little or no background in medicinal chemistry-a complete guide to the drug discovery process.

The Practice of Medicinal Chemistry


Author: Camille Georges Wermuth
Publisher: Elsevier
ISBN: 0080497772
Category: Science
Page: 736
View: 3481
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The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. * The only book available dealing with the practical aspects of medicinal chemistry * Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production * Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistry

Burger's Medicinal Chemistry and Drug Discovery, Therapeutic Agents


Author: Manfred E. Wolff
Publisher: Wiley-Interscience
ISBN: 9780471575603
Category: Science
Page: 879
View: 9673
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The final volume in the standard-setting reference on therapeutic designed drugs . . . BURGER'S MEDICINAL CHEMISTRY AND DRUG DISCOVERY, FIFTH EDITION, Volume 5: Therapeutic Agents This volume on Therapeutic Agents completes Burger's incisive, systematic examination of the fascinating new world of custom-designed therapeutic agents. Volume 5 highlights the link between chemical structure and biological activity, and explores chemotherapeutic agents, CNS and endocrine drugs, and radiological agents. It continues the authoritative coverage begun in earlier volumes and contains a comprehensive index for the entire edition. * Antimalarial agents * Agents affecting the action of * Cognition enhancers, agents, and prostaglandins pharmacodynamic models for * Agents affecting the action of Alzheimer's disease leukotrienes and thromboxanes * Antidepressant agent * Histamine H1 receptor antagonists * Antianxiety agents * Antiviral agents, RNA viruses * Antipsychotic agents other than HIV * Antihistamines, topical ocular * Radiopaques * Antiinflammatory steroids Essential to research in drug discovery and design, Volume 5 of Burger's Medicinal Chemistry and Drug Discovery is a cornerstone reference for professionals in the biopharmaceutical industry and academic research. Burger's Medicinal Chemistry, Fifth Edition consists of five volumes: * Volume 1: Principles and Practice (0-471-57556-9) 1994 * ". . . an essential addition to the libraries of any medicinal chemist . . . an outstanding work . . . highly praised as a fountain of information in drug studies and research."--Journal of Medicinal Chemistry * Volume 2: Therapeutic Agents (0-471-57557-7) 1996 * Volume 3: Therapeutic Agents (0-471-57558-5) 1996 * Volume 4: Therapeutic Agents (0-471-57559-3) 1997 * Volume 5: Therapeutic Agents (0-471-57560-7) 1997

Quantum Medicinal Chemistry


Author: Paolo Carloni,Frank Alber
Publisher: John Wiley & Sons
ISBN: 3527605304
Category: Science
Page: 294
View: 5182
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Computational methods are transforming the work of chemical and pharmaceutical laboratories. Increasingly faster and more exact simulation algorithms have made quantum chemistry a valuable tool in the search for active substances. Written by a team of leading international quantum chemists, this book is aimed at both beginners as well as experienced users of quantum chemical methods. All commonly used quantum chemical methods are treated here, including Density Functional Theory, quantum and molecular mechanical approaches. Numerous examples illustrate the use of these methods for dealing with problems in pharmaceutical practice, whether the study of inhibitor binding, identifying the surface load of active substances or deriving molecular descriptors using quantum chemical tools. For anyone striving to stay ahead in this rapidly evolving field.

The Handbook of Medicinal Chemistry

Principles and Practice
Author: Andrew Davis,Simon. E. Ward
Publisher: Royal Society of Chemistry
ISBN: 1849736251
Category: Science
Page: 753
View: 6028
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Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry has been revised and brought up to date to cover the past, present and future of the entire drug development process.

Burger's Medicinal Chemistry


Author: Alfred Burger,Manfred E. Wolff
Publisher: John Wiley & Sons
ISBN: N.A
Category: Chemotherapy
Page: 1354
View: 5251
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A thoroughly revised and expanded edition of a best-selling classic reference on principles and practice of medicinal chemistry and drug discovery. Volume 1 covered principles. Volumes 2 through 5 focus on drugs that target a particular organ or system. Volume 4 features authoritative and comprehensive surveys of cardiovascular drugs and chemotherapeutic agents, as well as information on radiological agents and opthalmic drugs. -- Volume 5 surveys central nervous system (CNS), endocrine, and immune system drugs.

Medicinal Chemistry

Principles and Practice
Author: Frank D. King,Royal Society of Chemistry (Great Britain)
Publisher: N.A
ISBN: 9780854046317
Category: Medical
Page: 448
View: 5477
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This book introduces the principles and practices of modern medicinal chemistry and covers all aspects of drug discovery from the initial lead to final development. It teaches how to convert a lead compound into a potential drug and provides recent case histories as examples of successes. Medicinal Chemistry is unique in dealing with the subject in such a practical way and is the only book currently available to bring together all areas of the subject in one volume. This breadth of coverage is supplemented by references to specialist monographs and reviews, where the reader can find more detail on specific topics of interest if required. Medicinal Chemistry is essential reading for students studying medicinal chemistry, as it provides a grounding in all the required disciplines and subjects. It will also be of great interest to chemists, biochemists and pharmacologists either already working in or contemplating a career in the pharmaceutical and allied industries.

Heterocyclic Chemistry in Drug Discovery


Author: Jie Jack Li
Publisher: John Wiley & Sons
ISBN: 1118354435
Category: Science
Page: 720
View: 1591
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Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Remington

The Science and Practice of Pharmacy
Author: David B. Troy,Paul Beringer
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781746731
Category: Medical
Page: 2393
View: 6810
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For over 100 years, Remington has been the definitive textbook and reference on the science and practice of pharmacy. This Twenty-First Edition keeps pace with recent changes in the pharmacy curriculum and professional pharmacy practice. More than 95 new contributors and 5 new section editors provide fresh perspectives on the field. New chapters include pharmacogenomics, application of ethical principles to practice dilemmas, technology and automation, professional communication, medication errors, re-engineering pharmacy practice, management of special risk medicines, specialization in pharmacy practice, disease state management, emergency patient care, and wound care. Purchasers of this textbook are entitled to a new, fully indexed Bonus CD-ROM, affording instant access to the full content of Remington in a convenient and portable format.

Biopsychologie


Author: John P. J. Pinel
Publisher: N.A
ISBN: 9783827372178
Category: Physiologische Psychologie - Lehrbuch
Page: 677
View: 1731
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Handbook of Drug Metabolism


Author: Thomas F. Woolf
Publisher: Marcel Dekker
ISBN: 9780824702298
Category: Medical
Page: 612
View: 9942
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Bringing together nearly forty collaborators from academic and industrial laboratories, this reference furnishes an overview of the subject from a historical, kinetic, and chemical context. A source of expertise for a rapidly changing and expanding field, the book provides a framework for drug metabolism in drug discovery and development. Containing tables, drawings, photographs, and equations, it highlights the importance of pharmacokinetics and cytochrome P450, explains clearance, volume of distribution, sequential metabolism, and nonlinear kinetics, summarizes concepts of Phase 1 and 2 metabolites, evaluates tertiary amine metabolism and reactive metabolite chemistry, and more.

An Introduction to Medicinal Chemistry


Author: Graham L. Patrick
Publisher: Oxford University Press
ISBN: 0199697396
Category: Medical
Page: 789
View: 2905
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This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.

Bioisosteres in Medicinal Chemistry


Author: Nathan Brown
Publisher: John Wiley & Sons
ISBN: 3527654321
Category: Medical
Page: 256
View: 1262
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Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

Annual Reports in Medicinal Chemistry


Author: N.A
Publisher: Academic Press
ISBN: 9780080583532
Category: Medical
Page: 317
View: 7898
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Annual Reports in Medicinal Chemistry

Pharmaceutical Chemistry


Author: Jill Barber,Chris Rostron
Publisher: Oxford University Press
ISBN: 0199655308
Category: Medical
Page: 368
View: 6548
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Taking medication is a common occurrence for many people, whether it is to soothe an aching head, regulate blood sugars, or treat life-threatening conditions such as HIV or cancer. Examining how drugs are manufactured, formulated, and the way that they work in our bodies, Pharmaceutical Chemistry provides a wide-ranging overview of organic chemistry as it is applied to the study and practice of pharmacy. FEATURES * Supports an integrated pharmacy education * Focuses on the fundamental ideas that first-year students need to fully grasp before progressing in their studies * Demonstrates the connections between scientific concepts and principles and how they are applied to pharmacy * Written and edited by experts who have a wealth of teaching experience COMPANION WEBSITE For registered adopters of the book: - Figures from the book, available to download For students: - Self-assessment questions for each chapter - Related additional resources ABOUT THE SERIES The Integrated Foundations of Pharmacy series supports those who are at the beginning of their journey to become a pharmacist. Students will begin to understand how a drug molecule is made; the process that turns it into a medicine; the role the pharmacist has when dispensing that medicine; and what happens in the body when it is taken. Most importantly, the series shows how each of these aspects are integrated, reflecting the most up-to-date teaching practices.

Organische Chemie für Dummies


Author: Arthur Winter
Publisher: John Wiley & Sons
ISBN: 3527822402
Category: Science
Page: 370
View: 3005
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Man könnte meinen, dass eine Wissenschaft, die sich hauptsächlich mit Verbindungen eines einzigen Elements auseinandersetzt, vergleichsweise übersichtlich ist. Doch Kohlenstoff ist ein ganz besonderes Element, denn Kohlenstoffverbindungen bilden die Grundlagen des Lebens. "Organische Chemie für Dummies" führt Sie in die Geheimnisse der organischen Verbindungen ein, erklärt Ihnen die Grundlagen der Spektrometrie und Spektroskopie, zeigt Ihnen, welche Reaktionen möglich und welche unmöglich sind und vieles mehr. Nach jedem Kapitel finden Sie Übungsaufgaben mit ausführlichen Lösungen. So unterstützt Sie das Buch bei Ihrem Einstieg in die Organische Chemie.

Medicinal Chemistry


Author: Norma K Dunlap,Donna M Huryn
Publisher: Garland Science
ISBN: 1351586211
Category: Political Science
Page: 375
View: 5137
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Medicinal Chemistry begins with the history of the field, starting from the serendipitous use of plant preparations to current practice of design- and target-based screening methods. Written from the perspective of practicing medicinal chemists, the text covers key drug discovery activities such as pharmacokinetics and patenting, as well as the classes and structures of drug targets (receptors, enzymes, nucleic acids, and protein-protein and lipid interactions) with numerous examples of drugs acting at each type. Selected therapeutic areas include drugs to treat cancer, infectious diseases, and central nervous system disorders. Throughout the book, historical and current examples illustrate the progress to market and case studies explore the applications of concepts discussed in the text. Each chapter features a Journal Club, as well as review and application questions to enhance and test comprehension. This textbook is ideal for upper-level undergraduates and graduate students taking a one-semester survey course on medicinal chemistry and/or drug discovery, as well as scientists entering the pharmaceutical industry.

Elemente der Syntheseplanung


Author: R.W. Hoffmann
Publisher: Spektrum Akademischer Verlag
ISBN: 9783827417251
Category: Science
Page: 206
View: 1366
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Bei der Syntheseplanung ist es wie beim Gebrauchtwagenkauf: Man kann folgenschwere Fehler machen, und jeder Fall ist anders! Und dennoch gibt es Tipps, woran man denken sollte und was man beachten muss! Dieses Buch führt in die elementaren Überlegungen ein, die man bei der Planung einer Synthese anstellen sollte. Diese Überlegungen illustriert R.W. Hoffmann mit zahlreichen Beispielen aus publizierten Synthesen. Bei jedem Beispiel gibt er die Originalliteraturstelle an, bei der Interessierte Details und weitere Erklärungen nachlesen können.

New Developments in Medicinal Chemistry


Author: Carlton Anthony Taft,Carlos Henrique Tomich de Paula Da Silva
Publisher: Bentham Science Publishers
ISBN: 1608051277
Category: Medical
Page: 162
View: 1282
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"This book is recommended for readers who are interested in or work with current theoretical and experimental research in medicinal chemistry, with an emphasis on computer aided-drug design and organic synthesis for therapeutic purposes. This book encompas"