Recombinant Antibodies for Cancer Therapy

Antibody technology is a subject of constant and rapid change. This volume, therefore, does not attempt to cover all possible current experimental approaches in the field.

Author: Martin Welschof

Publisher: Humana Press

ISBN: 1617372501

Category: Medical

Page: 481

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Since the advent of hybridoma technology more than two decades ago, numerous antibodies have entered the clinical setting as potent therapeutic agents. Their repeated application in humans, however, is limited by the development of human antimouse antibodies (HAMA) in the recipient, leading to allergic re- tions against the foreign murine protein and rapid neutralization. To circumvent these limitations many new antibodies have recently been tailored through recombinant antibody technology. The initial clinical data show encouraging results, thus demonstrating the potential of these new therapeutic agents. The purpose of Recombinant Antibodies for Cancer Therapy is to present a collection of detailed protocols in recombinant antibody technology. It is pri- rily addressed to scientists working on recombinant antibodies as well as cli- cians involved with antibody-based therapies. As with other volumes of this series, we placed the main focus on providing detailed protocols describing procedures step-by-step. Moreover, each protocol supplies a troubleshooting guide containing detailed information on possible problems and hints for pot- tial solutions. Antibody technology is a subject of constant and rapid change. This volume, therefore, does not attempt to cover all possible current experimental approaches in the field. Rather, we present carefully selected protocols, written by competent authors who have successfully verified the particular method described. Given our own professional backgrounds and interest in oncology, we chose to conc- trate chiefly on therapeutic agents for cancer patients.
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Mitigation of Cancer Therapy Side Effects with Light

In this book the authors attempt to portray the current status of the supportive care interventions that are possible with PBM using low level laser therapy (LLLT) in patients undergoing cancer treatment for solid tumours, harmatological ...

Author: Raj Nair

Publisher: Morgan & Claypool Publishers

ISBN: 9781681741390

Category: Medical

Page: 47

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'Light' from low level laser therapy, through a process called photobiomodulation (PBM), has been in existence in supportive care in cancer, in particular in the management of oral mucositis (OM) in patients undergoing chemotherapy, radiation therapy and haematopoietic stem cell transplantation. In this book the authors attempt to portray the current status of the supportive care interventions that are possible with PBM using low level laser therapy (LLLT) in patients undergoing cancer treatment for solid tumours, harmatological malignancies, and head and neck cancers.
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Everyone s Guide to Cancer Therapy

Equally informative and accessible, this comprehensive book navigates cancer patients and their caregivers through diagnosis, treatment, and supportive care.

Author: Dr. Andrew Ko

Publisher: Andrews McMeel Publishing

ISBN: 0740768573

Category: Health & Fitness

Page: 1024

View: 579

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Revised 5th Edition Praise for the first edition of Everyone's Guide to Cancer Therapy: How Cancer Is Diagnosed, Treated, and Managed Day to Day: A landmark book . . . So much of what the cancer patient must know to make informed decisions. --Publishers Weekly * A completely revised and accessible guide created by more than 100 esteemed oncologists for the millions of people whose lives are affected by cancer. The Centers for Disease Control reports that more than 20 million people in the U.S. are currently diagnosed with cancer, and 1.4 million people are expected to be diagnosed in the coming year. For the millions confronting cancer's many challenges, Everyone's Guide to Cancer Therapy: How Cancer Is Diagnosed, Treated, and Managed Day to Day relies on an esteemed panel of oncology specialists--more than 100 strong, and each experts in their fields-to completely update this definitive cancer resource. Equally informative and accessible, this comprehensive book navigates cancer patients and their caregivers through diagnosis, treatment, and supportive care. Every chapter has been methodically updated to include the latest medical breakthroughs and advice concerning cancer treatment, including: * Information on recently approved targeted therapies for various cancer types * The newest strategies in cancer diagnosis and prevention * Cancer biology: translating scientific discoveries into meaningful advances for patients * Supportive care and complementary approaches
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Handbook of Research on Advancements in Cancer Therapeutics

The Handbook of Research on Advancements in Cancer Therapeutics serves as a comprehensive guide in modern cancer treatment by combining and merging the knowledge from both cancer biology and the pharmacology of anticancer modalities.

Author: Kumar, Sumit

Publisher: IGI Global

ISBN: 9781799865315

Category: Medical

Page: 913

View: 640

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The complexity of cancer demands an integrated approach from both a cancer biology standpoint and a pharmaceutical basis to understand the different anticancer modalities. Current research has been focused on conventional and newer anticancer modalities, recent discoveries in cancer research, and also the advancements in cancer treatment. There is a current need for more research on the advances in cancer therapeutics that bridge the gap between basic research (pharmaceutical drug development processes, regulatory issues, and translational experimentation) and clinical application. Recent promising discoveries such as immunotherapies, promising therapies undergoing clinical trials, synthetic lethality, carbon beam radiation, and other exciting targeted therapies are being studied to improve and advance the studies of modern cancer treatment. The Handbook of Research on Advancements in Cancer Therapeutics serves as a comprehensive guide in modern cancer treatment by combining and merging the knowledge from both cancer biology and the pharmacology of anticancer modalities. The chapters come from multi-disciplinary backgrounds, including scientists and clinicians from both academia and various industries, to discuss nascent personalized therapies and big data-driven cancer treatment. While highlighting topic areas that include cancer prevention, cancer therapeutics, and cancer treatments through the lenses of technology, medicine/drugs, and alternate therapies, this book is ideally intended for oncologists, radiation oncologists, surgical oncologists, and cancer biologists, along with practitioners, stakeholders, researchers, academicians, and students who are interested in understanding the most fundamental aspects of cancer and the available therapeutic opportunities.
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Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy

Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment.

Author: Pawel Kalinski

Publisher: Springer

ISBN: 9783319675770

Category: Medical

Page: 264

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The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.
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Targeted Cancer Therapy

Emerging technologies in target identification, drug discovery, molecular markers, and imaging are rapidly changing the face of cancer. This book provides a foundation of knowledge in targeted cancer therapeutics.

Author: Razelle Kurzrock

Publisher: Humana Press

ISBN: 1603274235

Category: Medical

Page: 446

View: 290

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Emerging technologies in target identification, drug discovery, molecular markers, and imaging are rapidly changing the face of cancer. This book provides a foundation of knowledge in targeted cancer therapeutics. The treatment of cancer is increasingly being individualized, based on an understanding of underlying biologic mechanisms. Poised to change the landscape in oncology, this volume provides a state-of-the-art overview. It will be valuable to practicing and academic physicians, fellows, residents and students, as well as basic scientists, interested in the cancer field.
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Combination Cancer Therapy

The authors emphasize novel translational approaches that are rapidly moving from the laboratory benchtop to the patient's bedside as a new generation of cancer therapeutics.

Author: Gary K. Schwartz

Publisher: Springer Science & Business Media

ISBN: UOM:39015059148166

Category: Medical

Page: 284

View: 759

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reviews the concept of combining chemotherapeutic agents to increase cytotoxic efficacy in recent years; explains that as these drugs become part of clinical programs, it will be essential to understand how to combine them with traditional chemotherapy; addresses the critical understanding of these drug interactions for the successful introduction of these new agents into traditional clinical use; focuses on novel drug combinations with new agents that hold the most promise for the future of medical oncology.
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Applications of Viruses for Cancer Therapy

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Applications of viruses for cancer therapy".

Author: David T. Curiel

Publisher: Academic Press

ISBN: 9780123983428

Category: Medical

Page: 244

View: 639

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Provides information on the field of cancer research. It covers topics such as: Cancer Terminator Viruses and Approaches for Enhancing Therapeutic Outcomes, essign of improved oncolytic adenoviruses, and Adenovirus-based immunotherapies for cancer.
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Novel Approaches and Strategies for Biologics Vaccines and Cancer Therapies

This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies.

Author: Manmohan Singh

Publisher: Academic Press

ISBN: 9780124166615

Category: Medical

Page: 520

View: 624

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Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies
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Biodiversity Natural Products and Cancer Treatment

This book is the first of its kind in bringing together biodiversity, chemical ecology, phytochemistry and cancer therapy.

Author: Victor Kuete

Publisher: World Scientific

ISBN: 9789814583527

Category: Science

Page: 412

View: 537

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This book is the first of its kind in bringing together biodiversity, chemical ecology, phytochemistry and cancer therapy. The highlight of the book is an exhaustive compilation of scientific data on biodiversity of medicinal plants, biodiversity and metagenomics, chemical ecology of medicinal plants, chemical ecology of marine organisms, natural products from terrestrial microbial organisms with activity towards cancer cells, marine organisms, ethnopharmacology and phytotherapy, contribution of African flora in world fight against cancer, natural products derived from terrestrial plants with activity towards cancer cells and established anticancer drugs from natural origin. The book discusses the state-of-the-art of each topic to serve as reference resource tools for graduate students as well as scientists and scholars in pharmaceutical sciences, pharmacology, organic chemistry and biochemistry, pharmacognosy, phytochemistry, ethnomedicine and ethnopharmacology, complementary and alternative medicine, medical and public health sciences and others. It includes cutting-edge developments in anticancer discovery from both medicinal plants and organisms. Contents:Biodiversity of Medicinal Plants (Kirsten Yacoub, Katharina Cibis and Corinna Risch)Biodiversity and Metagenomics (Eva-Maria Surmann and Thomas Efferth)Chemical Ecology of Medicinal Plants (Christian Kersten, Stephanie Lenz and Janina Wich)Chemical Ecology of Marine Organisms (André Antunes and Thomas Efferth)Natural Products from Terrestrial Microbial Organisms with Cytotoxic Cell Cycle Inhibitors (Theresa Dreis, Caroline Gartner, Julia Krebs and Mathias Schneider)Marine Compounds (Jennifer Honek and Thomas Efferth)Ethnopharmacology and Phytotherapy (Ariane Löhnert, Susanne Löhnert, Viktoriya Mogilevskaya and Sandra Schick)Contribution of African Flora in a Global Fight Against Cancer (Victor Kuete and Thomas Efferth)Natural Products Derived from Terrestrial Plants with Activity Towards Cancer Cells (Sonia Falenska, Ina Kirmes, Stephanie Kletting, Irini Karagianni and Karen Duffy)Established Anticancer Drugs from Natural Origin (Clara Becker, Kerstin Hoffmann, Laura Hoffmann, Tanya King, Franziska Faulstich, Katrin Viertel, Victor Kuete and Thomas Efferth) Readership: Graduate students and scientists in pharmaceutical sciences, pharmacology, organic chemistry, biochemistry, pharmacognosy, phytochemistry, ethnomedicine & ethnopharmacology, compementary & alternative medicine, public health. Key Features:This book is the first of its kind bringing together biodiversity, chemical ecology, phytochemistry and cancer therapyThe book provides the state-of-the-art in anticancer discovery from medicinal plantsThe book also provides the state-of-the-art in anticancer discovery from marine organismsKeywords:Biodiversity;Cancer;Marine Products;Natural Products;Established Drugs
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