Cannabinoids and Pain

This book presents a well-balanced view of the potential medical use of cannabinoids in pain.

Author: Samer N. Narouze

Publisher: Springer Nature

ISBN: 9783030691868

Category: Medical

Page: 339

View: 942

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This book presents a well-balanced view of the potential medical use of cannabinoids in pain. It comprehensively covers the current challenges with medical cannabis utilization and provides recommendations for research and future directions. Organized into nine sections, the book begins with an introduction to medical cannabis, including its history, regulations, and the general attitudes of pain physicians on cannabis. Section two explores the biological effects of marijuana via the endocannabinoid system and its complex structure of receptors and enzymes. Sections three, four, and five then delve further into pharmacology and the mechanisms of action applicable to cannabinoids in managing pain. Timely and socially conscious, section six examines the benefits of substituting opioids with cannabinoids for preoperative management. Echoing the book's well-rounded content, sections seven and eight consider the challenges with medical cannabis, including safety and quality control, brain development risks, vaping hazards, and withdrawal. The book then closes with a look at the future of cannabis in medical research. Thoroughly and equitably composed, Cannabinoids and Pain is an invaluable resource for primary care physicians, pain and palliative care physicians, and oncologists.
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Use of Cannabis in Pain Management

Once this is understood, we focused on the most outstanding aspects concluded by those studies related to using cannabis and its derivatives in pain treatment.

Author: Pharmacology University

Publisher: Pharmacology University

ISBN:

Category: Health & Fitness

Page: 30

View: 649

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Pain is one of the main reasons for consultation in health centers around the world. It is an unpleasant symptom that develops from a neurological response to physical or chemical stimuli representing actual or potential damage to tissues and can affect various aspects of the sufferer's life, deteriorating their quality of life. Man's search for pain relief is almost as old as his existence. The ancient shamans, the first physicians in history, dedicated their studies and practices to alleviate pain. Trying with different plants and performing rudimentary and potentially deadly surgical procedures, an endless number of processes whose purpose was nothing more than to relieve pain in all its forms and intensities. One of the most remarkable findings in ancient medicine is the discovery of the analgesic properties of the cannabis plant. This observation was made at least 6,000 years ago and is still valid today. The liberation boom regarding legal restrictions in cannabis use and research has permitted the scientific exploration of the plant's properties, applied to medicine, health, and wellness. This has led to new modern studies exploring the effectiveness of cannabinoid treatment for pain as an adjuvant in the company of other analgesics and by itself. The future of medical cannabis looks promising according to this research. Especially for patients with chronic pain conditions, such as rheumatoid arthritis, fibromyalgia, or neuropathic pain, especially considering that the adverse effects are considerably less and the many administration methods available, many of which are minimally invasive, convenient, and easy to use. In this audiobook, we explore the effects of cannabis on pain relief. We begin defining the concept of what pain is and its function in the body. Then investigate the role of the endocannabinoid system in the part of the nervous system responsible for the transmission of pain, as the scientific basis of the findings described throughout this text. Once this is understood, we focused on the most outstanding aspects concluded by those studies related to using cannabis and its derivatives in pain treatment. Likewise, we discuss how the properties of cannabinoids when applied to the management of this condition with a scientific approach and using testimonies from various patients with different diseases with pain as the main symptom. We can see how the use of the plant helped these people improve their lives. Finally, we study some homemade cannabis-based products which might be beneficial in managing certain types of pain and even some conditions where the use of the plant could be contraindicated.
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Cannabis and Chronic Pain

The role of cannabis plant and its components, called cannabinoids, as adjuvant analgesics in the treatment of chronic pain, has been the subject of longstanding controversy.Flowering plants within the genus Cannabis (also known as ...

Author: Arnold Kuntz Ph D

Publisher:

ISBN: 9798567183106

Category:

Page: 60

View: 500

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Pain is one of the most common symptoms of disease. Acute pain is usually successfully managed with non-steroidal anti-inflammatory drugs (NSAIDs) and/or opioids, but chronic pain is often difficult to treat and can be very disabling. An adjuvant is a drug that is not primarily intended to be an analgesic but can be used to reduce pain either alone or in combination with other pain medications. Some of these drugs have been known for some time, but their acceptance has waxed and waned over time. However, new approaches to targeting the pain pathway have been developed and adjuvant analgesics continue to attract both scientific and medical interest as constituents of a multimodal approach to pain management. The role of cannabis plant and its components, called cannabinoids, as adjuvant analgesics in the treatment of chronic pain, has been the subject of longstanding controversy.Flowering plants within the genus Cannabis (also known as marijuana) in the family Cannabaceae have been cultivated for thousands of years in many parts of the world for spiritual, recreational and medicinal purposes. Preparations of the cannabis plant, which are taken by smoking or oral ingestion, have been observed to produce analgesic, anti-anxiety, anti-spasmodic, muscle relaxant, anti-inflammatory and anticonvulsant effects. However, the prohibition of cannabis cultivation, supply and possession from the middle of the 20th century (due to its psychoactivity and potential for producing dependence), has impeded cannabis research. In recent years there is a growing debate about cannabis use for medical purposes. In many countries cannabis use for medical reasons is legal and some countries have also decriminalized or legalized the recreational use of cannabis. The term medical cannabis is used to refer to the physician-recommended use of cannabis and its constituents, cannabinoids, to treat disease or improve symptoms. The use of cannabis and cannabinoids may be limited by its psychotropic side effects (e.g., euphoria, anxiety, paranoia) or other central nervous system (CNS)-related undesired effects (cognitive impairment, depression of motor activity, addiction), which occur because of activation of cannabinoid CB1 receptors in the CNS . As interest in the use of cannabinoids as adjunctive therapy for pain management has increased in the last decades, there has been a continuing need for an increase in cannabis research and bridging the knowledge gap about cannabis and its use in pain treatment. Therefore, research on cannabis and cannabinoids has increased dramatically in recent years. However, there are several obstacles that need to be overcome, such as the regulations and policies that restrict access to the cannabis products, funding limitations, and numerous methodological challenges (drug delivery, the placebo issue, etc.).
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ROLE OF CANNABIS AND CANNABINOIDS IN PAIN MANAGEMENT AND SOCIAL ASPECTS OF MEDICAL CANNABIS LEGALIZATION

Introduction and objectivesAim of the study was to review the quality, safety, and efficacy of medical cannabis (MC).

Author: Ruta Jaliniauskaite

Publisher:

ISBN: OCLC:1163814136

Category:

Page:

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Introduction and objectivesAim of the study was to review the quality, safety, and efficacy of medical cannabis (MC). Botanical, regulatory and social-epidemiological aspects were included. Methods We did a search of PubMed, Elsevier, and the Cochrane databases up to 30th of April, 2019 using u201ccannabisu201d, u201ccannabinoidsu201d as keywords. We identified 29 clinical trials and 17 epidemiological studies meeting our inclusion criteria.Results568 molecules and 104 cannabinoids are identified from Cannabis. Number of pharmaceutical forms are available including capsules, tinctures, oils, dermal patches, sprays, smoking formulations. The variety of active compounds and absence of pharmacopoeia articles for quality standardization makes difficult to classify and study safety and efficacy of MC in pain control. In the latest research, MC based therapy reduced pain 10,7% compared to placebo (4,5%) using VAS in patients with chronic pain, however some studies showed no change. Nabiximols showed reduction in muscle spasms by 1.3 compared to placebo - 0.4 points. Consumption of marijuana in US by 2004 reached 7.13% in states with and 3.57% without medical cannabis laws (MCL) as well as marijuana abuse 1,27% and 2,61% respectively. In 2016 Israel became the leading country for cannabis consumption as the prevalence rate after MCL implementation reached 27% of the entire adult population. (Fig. 2) Cannabis was well tolerated and effectively reduced pain for patients with neuropathy. Moreover, it effectively reduced pain and muscles spasms for patients with multiple sclerosis. (Fig. 3)ConclusionsMC products may reduce usage for pain control medicines, but larger-scale clinical trials are necessary to prove therapeutic benefits to different types of pain, as well as define exact dosage and implement pharmacopeia monographs standardization. MC legalization causes the increase of cannabis abuse and it may negatively affect public health situation on a country level.
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Cannabis Nursing

There is also a 5 credit CEU course in cannabis medicine based on this book. The course is $40 and the offer is located at the end of this book.

Author: Steven Leonard-Johnson Rn

Publisher: Cannabis Nursing Series, Volum

ISBN: 1724047558

Category: Medical

Page: 106

View: 627

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Comprehensive, precise and readable. Written by a registered nurse and best selling cannabis author. You have an Endo-Cannabinoid System (ECS). It helps regulate many bodily systems. Mother's milk has endo-cannabinoids and you produce your own, or not. You could be suffering from clinical Endo-Cannabinoid Deficiency Syndrome (CEDS). The Hemp family of plants is the best source of cannabinoids. One cannabinoid, CBD, just maybe the greatest supplement of our lifetime. This book on cannabinoid medicine will focus on one aspect of treatment, cannabinoid analgesia. In order to fully understand mechanisms of action of cannabinoids in pain management, it will be necessary to give an overview of the endocannabinoid system (ECS), a system many health professionals have never heard of, a system we were never taught about in our formal health education. There is also a 5 credit CEU course in cannabis medicine based on this book. The course is $40 and the offer is located at the end of this book.
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Cannabis and CBD for Health and Wellness

With information on cannabis forms (tinctures, topicals, edibles, flowers, concentrates), methods of ingestion (smoking, vaping, capusles, patches, creams, and more), dosing and microdosing, safety and storage, caregiving, and effectivess ...

Author: Aliza Sherman

Publisher: Ten Speed Press

ISBN: 9781984856869

Category: Health & Fitness

Page: 176

View: 882

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A safe, comprehensive, and easy-to-use guide to using cannabis—including CBD and THC—to ease chronic and acute health issues such as pain, insomnia, inflammation, depression, anxiety, grief, stress, and more, from the founder of a global cannabis wellness network and an osteopathic physician. With legalization of recreational cannabis in 10 states and medical marijuana in 33 states, interest is growing in cannabis-related health products, especially those made with CBD—a cannabinoid that has healing properties without the psychoactive effects of THC. Cannabis and CBD for Health and Wellness demystifies cannabis and its history, and explains in simple and straightforward language how to use it to treat myriad health and lifestyle issues. With information on cannabis forms (tinctures, topicals, edibles, flowers, concentrates), methods of ingestion (smoking, vaping, capusles, patches, creams, and more), dosing and microdosing, safety and storage, caregiving, and effectivess for self-care, physical fitness, sexual arousal, aging, and more, this is the only book you need to start using cannabis—in a targeted and safe way—for better health.
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CBD Oil for Chronic Pain Effective Remedy for Recurrent and Chronic Pain

But as medical researchers learned more, and the stories from tens of thousands of people began to stack up, the truth was undeniable.

Author: Dr Karl Burmer

Publisher: Independently Published

ISBN: 1798062569

Category: Health & Fitness

Page: 40

View: 109

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CBD (Cannabidiol) is a compound found in the Cannabis plant. It can be used in several different ways including vaping, tinctures, capsules, and edibles.Unlike its close relative, THC (Tetrahydrocannabinol), CBD is completely non-psychoactive. This allows us to benefit from the many health properties of the Cannabis plant without the negative side effects of "getting high."Because of this, CBD became a very popular option for those seeking a natural alternative to treat conditions such as chronic pain, multiple sclerosis, PTSD, epilepsy and other mental disorders.At first, many were skeptical, thinking that a natural compound, let alone a Cannabis-compound, could effectively treat such a wide range of conditions. But as medical researchers learned more, and the stories from tens of thousands of people began to stack up, the truth was undeniable. CBD works.For starters, CBD inherits many of the medicinal properties of Cannabis such as being anti-inflammatory and anti-anxiolytic. This allows it to provide natural stress, anxiety and pain relief.But this alone is not what allows CBD to benefit so many conditions.What allows it to effectively treat so many conditions, and maintain health and wellness in the body, is how the cannabinoids found in CBD interact with receptors throughout our body.In 1988, the first cannabinoid receptor was discovered in the brain of a rat. Researchers found that these receptors reacted specifically to THC, and were found primarily found in regions of the brain responsible for mental and physiological processes such as memory, high cognition, emotion, and motor coordination. Few years later, in 1993, the second cannabinoid receptor was found as part of the immune and central nervous systems. It was then that researchers started to realize that they may have been onto something, but these receptors were only found in rodents, so what is the big deal right?Fast forward to 1995, researchers discovered that these receptors, now officially referred to as the CB1 receptor and CB2 receptor, were found not only in rats, but within thousands of other species, including humans.Thanks to advancements in technology and knowledge and tons of clinical trials, researchers were able to reverse engineer what they have discovered, trace back through the metabolic pathways of various cannabinoids, and uncover an entirely unknown signaling system between the CB1 and CB2 receptors in our bodies and receptors found in Cannabis compounds, which they called "endocannabinoids."Due to the role of endocannabinoids in this system, the system was officially named the Endocannabinoid System (ECS).As researchers learned more about the ECS, they discovered that it was a vital component in maintaining the body's homeostasis, which is the ideal balance between interdependent elements in the body.To give you an idea on how the ECS helps maintain homeostasis, Let me give you an example. When we become stressed, our mind releases cortisol, which is the compound responsible for how we feel when we are stressed. Cortisol can be helpful when we need to react quickly to a dangerous situation; however too much disruptions in the natural balance of our body and mind can result in serious health problems.When certain endocannabinoids are introduced into the body, it not only helps provide stress relief, it helps manage our perception of stress so that we can look at the situation with a clear mind, and make the best decision.With all the scientific jargon, this last section may have been a little confusing. So just to clarify. Scientists discovered that there are systems in our bodies that are solely dependent on their interaction with cannabinoids, and these systems are part of vital functions in our bodies.Basically, our bodies were designed to work with cannabinoids, and they can even be considered as essential to our overall health and wellness.
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Managing Acute Chronic and Recurrent Pains With CBD Oil

This is why more people are embracing CBD oil as a safer alternative to manage pains. The book is written in simple English devoid of medical jargons to carry readers from different background along.

Author: Kurt McDermott

Publisher: Independently Published

ISBN: 1982932767

Category:

Page: 153

View: 381

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ARE YOU SUFFERING FROM ACUTE OR CHRONIC PAIN? ARE YOU TIRED OF THAT RECURRENT PAIN? THEN YOU ARE NOT ALONE. GRAB THIS BOOK AND LEARN ALL YOU COULD DO WITH CBD OIL TO END THAT PAIN TODAY.In his Medical Marijuana Clinic, Kurt McDermott has taught people of all ages and walks of life how to safely extract and use CBD oil to treat acute, chronic and recurrent pain without resorting to prescription painkillers, (opioid-based drugs), physical therapy or invasive surgery. Traditional Pain pills like Hydrocodone and Oxycodone are increasingly addictive making them unsafe for managing chronic pains. According to the CDC, around 90 Americans die from opioid overdoses every day, which is above the number of people who die from car crashes daily. This is why more people are embracing CBD oil as a safer alternative to manage pains. The book is written in simple English devoid of medical jargons to carry readers from different background along. Whether you suffer from Emotional Pain, Sensory Pain, Visceral Pain, Neuropathic Pain, Cancer pain, Endometriosis (Menstrual Cramp), pain resulting from Arthritis, Inflammatory Bowel Disease, Graves' Disease, Multiple Sclerosis, Lupus, Carpal tunnel syndrome Hashimoto's Thyroiditis, Rheumatoid Arthritis, Celiac Disease, Fibromyalgia, Back Pain caused by Degenerative Intervertebral Discs, Migraine etc, CBD oil is a revolutionary and proven approach to self-care that promises optimal health with no adverse effect. Grab this guide today and learn: - What is Cannabis? - Difference between CBD and THC - What Cannabinoids are- What Cannabidiol (CBD) is - A List of Some Prominent Cannabinoids in Cannabis- Entourage Effect of Cannabinoids - Pharmacology of the Endocannabinoid System - Impact of Medical Cannabis on Health Care - The Pain Mechanism - Types of Pain- Pain Processing In The Brain - The Pain Matrix - Inhibiting Pain Transmission - Scientific Methods for Testing Hemp Plant for CBD Content and Purity - How CBD is synthesized in the laboratory - What CBD Oil is - Picking the Right Cannabis Strain to Extract CBD Oil - How to Extract High Quality CBD Oil At Home - Important Facts About CBD Oil - What Hemp Oil is - Difference Between Cannabis and the Hemp Plant - Constituent of Hemp Oil - Benefits of Hemp Oil - How to Manage Pain with CBD Oil - How the Endocannabinoid System Handles Pain and Inflammation - How to use CBD Oil to Modulate Cancer - How to use CBD Oil to Modulate Inflammatory, Degenerative and Crystal Arthritis - How Cannabinoid Receptors are activated in Joints to Modulate Pains and Inflammation - How to Modulate Autoimmune Diseases (e.g., Hashimoto's Thyroiditis, Rheumatoid Arthritis, Celiac etc) with CBD Oil - Understand Oxidative Stress in Autoimmune Disease - The types of Fibromyalgia - Modulating Pain in Fibromyalgia with CBD oil - How to CBD oil modulate Endometriosis (Menstrual Cramp) - Causes of Back Pain- How CBD oil Modulate Back Pain Caused by Degenerative Intervertebral Discs - Migraine Headache- How CBD Oil Modulating Migraine - Methods of Consuming CBD Oil for Pain - Guideline to Purchase CBD Oil- Marijuana Based Medications Not Available in the United States - Safety Concerns of CBD oil- Managing Pains in Pets with CBD Oil - The Legality of CBD- FDA's Enforcement Actions Relating to "CBD Oils" - Legal status of CBD at the Federal & State Levels - What the Farm Bill is all about- What is means to Cultivate hemp outside the purview of the Farm Bill Do not wait any longer, download "Managing Acute, Chronic and Recurrent Pain with CBD Oil"
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Effect of Cannabinoids on Pain stimulated and Pain depressed Behavior in Rats

Cannabinoids produce antinociception in many preclinical models of acute and chronic pain.

Author: Andrew Kwilasz

Publisher:

ISBN: OCLC:849951902

Category:

Page:

View: 528

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Cannabinoids produce antinociception in many preclinical models of acute and chronic pain. In contrast, cannabinoids produce inconsistent analgesia in humans, showing little or no efficacy in treating acute pain, with modest efficacy in treating chronic inflammatory pain. This discrepancy may reflect an overreliance on preclinical assays of pain-stimulated behaviors, defined as behaviors that increase in rate or intensity following delivery of a noxious stimulus. In these assays, antinociception is indicated by a reduction in pain-stimulated behaviors, and antinociception is produced either by a reduction in sensory sensitivity to the noxious stimulus (i.e. true analgesia) or by false positive motor impairment. This dissertation addresses this weakness by complementing cannabinoid effects in conventional assays of pain-stimulated behavior with their effects in novel assays of pain-depressed behavior. Pain-depressed behaviors are defined as behaviors that decrease in rate or intensity following presentation of a noxious stimulus. Motor impairment does not produce false positive antinociception in assays of pain-depressed behavior, because antinociception is indicated by a blockade or reversal of pain-induced behavioral depression. In this dissertation, an intraperitoneal (IP) injection of lactic acid served as an acute noxious stimulus to stimulate stretching (pain-stimulated behavior) or depress intracranial self-stimulation (ICSS) (pain-depressed behavior), whereas, IP injection(s) of lipopolysaccharide (LPS) served as a chronic/acute inflammatory-related noxious stimulus to stimulate mechanical allodynia (pain-stimulated behavior) or depress ICSS (pain-depressed behavior). Cannabinoids tested in the assays of acid-stimulated stretching and acid-depressed ICSS included: mixed CB1R/CB2R agonists THC and CP55940, drugs that modulate levels of the endogenous cannabinoid agonist anandamide (URB597 and PF3845), and a selective CB2R agonist, GW405833. THC was also tested in assays of LPS-stimulated mechanical allodynia and LPS-depressed ICSS. In general, mixed CB1R/CB2R agonists were ineffective or exacerbated pain-depressed behavior regardless of noxious stimulus. Contrastingly, URB597 and GW405833 produced antinociception in the assay of acid-depressed ICSS; however their effects were not mediated by CBRs. All compounds produced antinociception in the assay of pain-stimulated behavior, except for PF3845. These results suggest that assays of pain-depressed behavior may be useful for development of cannabinoid analgesic medications, but that further research is needed to determine mechanisms underlying cannabinoid-mediated antinociception in these assays.
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CBD Oil for Chest Pain Potent Remedy for Inflammation Lining of the Lung and Chest

But as medical researchers learned more, and the stories from tens of thousands of people began to stack up, the truth was undeniable.

Author: Dr Tom Warner

Publisher: Independently Published

ISBN: 1092441891

Category: Health & Fitness

Page: 50

View: 386

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INTRODUCTIONCBD (Cannabidiol) is a compound found in the Cannabis plant. It can be used in several different ways including vaping, tinctures, capsules, and edibles.Unlike its close relative, THC (Tetrahydrocannabinol), CBD is completely non-psychoactive. This allows us to benefit from the many health properties of the Cannabis plant without the negative side effects of "getting high."Because of this, CBD became a very popular option for those seeking a natural alternative to treat conditions such as chronic pain, multiple sclerosis, PTSD, epilepsy and other mental disorders.At first, many were skeptical, thinking that a natural compound, let alone a Cannabis-compound, could effectively treat such a wide range of conditions. But as medical researchers learned more, and the stories from tens of thousands of people began to stack up, the truth was undeniable. CBD works.For starters, CBD inherits many of the medicinal properties of Cannabis such as being anti-inflammatory and anti-anxiolytic. This allows it to provide natural stress, anxiety and pain relief.But this alone is not what allows CBD to benefit so many conditions.What allows it to effectively treat so many conditions, and maintain health and wellness in the body, is how the cannabinoids found in CBD interact with receptors throughout our body.In 1988, the first cannabinoid receptor was discovered in the brain of a rat. Researchers found that these receptors reacted specifically to THC, and were found primarily found in regions of the brain responsible for mental and physiological processes such as memory, high cognition, emotion, and motor coordination.Two years later, in 1993, the second cannabinoid receptor was found as part of the immune and central nervous systems. It was then that researchers started to realize that they may have been onto something, but these receptors were only found in rodents, so what is the big deal right?Fast forward to 1995, researchers discovered that these receptors, now officially referred to as the CB1 receptor and CB2 receptor were found not only in rats, but within thousands of other species, including humans.Thanks to advancements in technology and knowledge and tons of clinical trials, researchers were able to reverse engineer what they discovered, trace back through the metabolic pathways of various cannabinoids, and uncover an entirely unknown signaling system between the CB1 and CB2 receptors in our bodies and receptors found in Cannabis compounds, which they called "endocannabinoids."Due to the role of endocannabinoids in this system, the system was officially named the Endocannabinoid System (ECS).As researchers learned more about the ECS, they discovered that it was a vital component in maintaining the body's homeostasis, which is the ideal balance between interdependent elements in the body.To give you an idea on how the ECS helps maintain homeostasis, Let me give you an example. When we become stressed, our mind releases cortisol, which is the compound responsible for how we feel when we are stressed. Cortisol can be helpful when we need to react quickly to a dangerous situation; however too much disrupts the natural balance of our body and mind can result in serious health problems.When certain endocannabinoids are introduced into the body, it not only helps provide stress relief, it helps manage our perception of stress so that we can look at the situation with a clear mind, and make the best decision.With all the scientific jargon, this last section may have been a little confusing. So just to clarify... Scientists discovered that there are systems in our bodies that are solelydependenton their interaction with cannabinoids, and these systems are part of vital functions in our bodies.Basically, our bodies were designed to work with cannabinoids, and they can even be considered as essential to our overall health and wellness.
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