Drug Treatment of Hyperlipidemia

Originally published in 1991, ' Drugs Treatment of Hyperlipidemia' is a collection of essays that include studies on lipid metabolism, diagnosis of lipoprotein disorders, detection and treatment of dyslipoporteinemia and trials of lipid ...

Author: B. Rifkind

Publisher: CRC Press

ISBN: 0824785126

Category: Medical

Page: 280

View: 465

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Originally published in 1991, ' Drugs Treatment of Hyperlipidemia' is a collection of essays that include studies on lipid metabolism, diagnosis of lipoprotein disorders, detection and treatment of dyslipoporteinemia and trials of lipid lowering drugs amongst its topics
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Hyperlipidemia

Biochemical findings indicate how lipoproteins interact and exert their physiological and pathophysiological effects. Lipids and lipoproteins, in general are discussed. The plasma cholesteral health consequences involve lipid distribution.

Author: Basil M. Rifkind

Publisher: Saunders

ISBN: UOM:39015000889991

Category: Hyperlipemia

Page: 396

View: 532

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Abstract: The diagnosis and management of hyperlipidemic and hyperlipoproteinemic states are explored from various points of view. Epidemiological observations show an inverse relationship between high density lipoprotein levels and coronary heart disease. Biochemical findings indicate how lipoproteins interact and exert their physiological and pathophysiological effects. Lipids and lipoproteins, in general are discussed. The plasma cholesteral health consequences involve lipid distribution. Research, review and evolution of clinical trials of lipid lowering to prevent coronary heart disease are included. Specific topics include various aspects of hyperlipoproteinemia: classification, diagnosis, primary and secondary types, genetic characteristics, dietary and drug treatment, and surgical management.
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Combination Therapy In Dyslipidemia

Comprising contributions from leading lipidologists from around the world, this book presents the latest and most comprehensive knowledge on the different options for combination therapy of dyslipidemia and includes discussion of future ...

Author: Maciej Banach

Publisher: Springer

ISBN: 9783319204338

Category: Medical

Page: 205

View: 359

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Comprising contributions from leading lipidologists from around the world, this book presents the latest and most comprehensive knowledge on the different options for combination therapy of dyslipidemia and includes discussion of future therapies that are currently in late stages of clinical evaluation. Dyslipidemia is a leading cause of cardiovascular morbidity and mortality and most patients with this condition fail to achieve adequate control of their serum lipid levels with monotherapy. However, recent US and European guideline recommendations, based on randomized, controlled trials, fail to discuss combination therapy options for patients with dyslipidemia. Statins remain the mainstay of drug therapy for hyperlipidemia and chapters in this book specifically examine the role of add-on therapy with different agents modulating the different lipid fractions in the blood, e.g. bile acid sequestrants, fibric acid derivatives (fibrates), omega-3 fatty acids (fish oils), inhibitors of Niemann-Pick C1 like 1 (NPC1L1) protein, cholesteryl ester transfer protein (CETP), apolipoprotein B-100 and microsomal triglyceride transfer protein (MTP) and the emerging proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. There is additional discussion of the role of non-drug therapy options such as nutraceuticals, functional foods and lipoprotein apheresis. The book also discusses the combination of antihypertensive drugs with lipid-lowering drugs in the management of cardiovascular risk in patents with dyslipidemia.
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Cholesterol Lowering Therapies and Drugs

Covering recent progresses in cholesterol-lowering drugs and therapy, this book describes the natural and pharmaceutical products that are in clinical uses to lower cholesterol and lipids and compares these drugs in responses to different ...

Author: Chunfa Huang

Publisher: BoD – Books on Demand

ISBN: 9789535127345

Category: Medical

Page: 186

View: 551

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Using natural products and developing pharmaceutical drugs are emerging topics to reduce blood cholesterol levels for preventing heart disease and stroke. Covering recent progresses in cholesterol-lowering drugs and therapy, this book describes the natural and pharmaceutical products that are in clinical uses to lower cholesterol and lipids and compares these drugs in responses to different diseases such as homozygous familial hypercholesterolemia, atherosclerosis, cardiovascular disease, and cancer. The relationship between ethnicity and cholesterol-lowering drug responses is also reviewed. Each chapter is a building block for the book, but each individual chapter is also a complete subject package for the readers. Researchers from basic and clinic science interested in lipid and cholesterol metabolism, regulation, and lowering will find this book very useful. Features: - Up-to-date information of the molecular mechanisms of cholesterol lowering, the drugs from natural and pharmaceutical products, and their associated therapeutic strategies in human diseases. - Discussion of the pathogenesis of several human diseases, which are associated with high cholesterol levels and evaluation of the results of different cholesterol-lowering drug treatment in these diseases. - Discussion of the combinations of cancer chemotherapy and cholesterol lowering in potential cancer treatment and cancer prevention by cholesterol-lowering drugs. - Critical analysis of the effect of ethnicity on responses to cholesterol-lowering drug therapy leading to rational dose adjustment of cholesterol-lowering drugs for different people use.
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Treatment of dyslipidaemias

Preventing the progress of arterial disease in those already affected (the most important patient group to be treated) Decreasing the risk of atherosclerotic arterial disease guided by the total risk (combined effect of risk factors). he ...

Author: Sics Editore

Publisher: SICS Editore

ISBN: 9788869305252

Category: Medical

Page:

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Preventing the progress of arterial disease in those already affected (the most important patient group to be treated) Decreasing the risk of atherosclerotic arterial disease guided by the total risk (combined effect of risk factors). he assessment of the risk for arterial disease may be facilitated by the use of different risk calculators (e.g. SCORE , HeartScore ). Changing living habits is the primary target in all patients. Rule out secondary hypercholesterolaemia (e.g. associated with hypothyroidism) before starting drug treatment. The general goal of treatment is to maintain plasma LDL cholesterol concentration (calculator ) under 3.0 mmol/l (in high-risk individuals under 2.5 mmol/l and in very high-risk individuals under 1.8 mmol/l, if possible). Changing of plasma HDL cholesterol or triglyceride concentrations is not a treatment goal, but they are measured for risk assessment.
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HMG CoA Reductase Inhibitors

It sets the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating atherosclerosis and its sequelae. This topical volume.

Author: Gerd Schmitz

Publisher: Birkhäuser

ISBN: 9783034881357

Category: Medical

Page: 151

View: 661

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HMG-CoA reductase inhibitors (statins) are established drugs for the treatment of hypercholesterolemia. Furthermore, they induce regression of vascular atherosclerosis as well as reduction of cardiovascular-related morbidity and death in patients with and without coronary artery disease. This book deals with statins which have substantially altered the approach to therapy of atherosclerosis and its sequelae. Emphasis is placed on the scientific background to the discoveries and the development of the therapy, including an overview of the current state of knowledge of the drugs. Clinical data are reviewed extensively. This book not only provides the reader with valuable information but also stimulates further research into the pathogenesis of atherosclerosis and the mechanisms behind the action of effective statins. It sets the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating atherosclerosis and its sequelae. This topical volume...
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Fast Facts Hyperlipidemia

Directed at a broad range of healthcare professionals, from primary care physicians to specialists, this updated sixth edition addresses the importance of considering lipoprotein particles, not just their lipids.

Author: A. Sniderman

Publisher: Karger Medical and Scientific Publishers

ISBN: 9783318067873

Category: Medical

Page: 166

View: 918

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'Fast Facts: Hyperlipidemia' is a crisp and accurate summary of lipid disorders, with clear language and illustrations. Directed at a broad range of healthcare professionals, from primary care physicians to specialists, this updated sixth edition addresses the importance of considering lipoprotein particles, not just their lipids. The renowned authors, acknowledging the confusion surrounding the place of statins, carefully unpick clinical trial evidence and discuss guideline recommendations. The result is a clear and logical approach to the management of hyperlipidemia. Table of Contents: • Lipids and lipoprotein particles • Epidemiology and pathophysiology • Familial hypercholesterolemia • Polygenic hypercholesterolemia and combined hyperlipidemia • Hypertriglyceridemia • Familial dysbetalipoproteinemia • Dyslipidemia in insulin resistance, the metabolic syndrome and diabetes mellitus • Secondary hyperlipidemia • Dietary treatment • Drug treatment • When to treat • Biochemical tests
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Fast Facts Hyperlipidemia

Directed at a broad range of healthcare professionals, from primary care physicians to specialists, this updated fifth edition addresses the importance of considering lipoprotein particles, not just their lipids.

Author: Allan Sniderman

Publisher: Karger Medical and Scientific Publishers

ISBN: 9781905832637

Category: Medical

Page: 142

View: 466

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'Fast Facts: Hyperlipidemia' provides a crisp and accurate summary of lipid disorders using clear language and illustrations. Directed at a broad range of healthcare professionals, from primary care physicians to specialists, this updated fifth edition addresses the importance of considering lipoprotein particles, not just their lipids. The authors, renowned experts from the UK and USA, interpret clinical trial evidence in the context of pathogenesis and provide practical solutions to the routine problems encountered in the clinical management of hyperlipidemias. Contents: • Lipids and lipoproteins - structure and physiology • Epidemiology and pathophysiology • Familial (monogenic) hypercholesterolemia • Polygenic hypercholesterolemia and combined hyperlipidemia • Hypertriglyceridemia • Familial dysbetalipoproteinemia • Dyslipidemia in insulin resistance, the metabolic syndrome and diabetes mellitus • Secondary hyperlipidemia • Dietary treatment • Drug treatment • When to treat • Biochemical tests • Useful resources
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The John Hopkins Textbook of Dyslipidemia

The first comprehensive text on dyslipidemia from a major academic institution, this book covers all aspects of dyslipidemia as it relates to human disease, including coronary artery disease, cerebrovascular disease, peripheral vascular ...

Author: Peter O. Kwiterovich

Publisher: Lippincott Williams & Wilkins

ISBN: 9781451149159

Category: Medical

Page: 320

View: 826

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The first comprehensive text on dyslipidemia from a major academic institution, this book covers all aspects of dyslipidemia as it relates to human disease, including coronary artery disease, cerebrovascular disease, peripheral vascular disease, and pancreatitis. The material is presented in a clinician-friendly format and includes references for additional reading. Reflecting current guidelines from the National Cholesterol Education Program, the book explains why, when, and how to treat dyslipidemia. Coverage includes dietary treatment, drug treatment, and recommendations for special populations such as patients with coronary heart disease, patients at high risk for coronary heart disease, patients with diabetes, women, older adults, young adults, and racial and ethnic groups.
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