Focus on Signal Transduction Research

Signal transduction is any process by which a cell converts one kind of signal or stimulus into another.

Author: Gavin McAlpine

Publisher: Nova Publishers

ISBN: 1600213766

Category: Medical

Page: 240

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Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.
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Cellular Signal Transduction in Toxicology and Pharmacology

Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets.

Author: Jonathan W. Boyd

Publisher: Wiley

ISBN: 9781119060260

Category: Science

Page: 336

View: 944

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Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques
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Focus on Bipolar Disorder Research

Furthermore, recent research unmasked some hitherto unrecognized and unexpected ... progress in research work concerning intracellular signal transduction ...

Author: Malcomb R. Brown

Publisher: Nova Publishers

ISBN: 1594540594

Category: Science

Page: 198

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In a world permeated with stress, bipolar disorders have become an all too common occurrence. There are millions of people throughout the world suffering from this disorder. Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in a person's mood, energy, and ability to function. Different from the normal ups and downs, the symptoms of bipolar disorder are severe. They can result in damaged relationships, poor job or school performance, and even suicide. The primary psychological factor implicated in the manifestation of bipolar disorder is stressful life events. These can range from a death in the family to the loss of a job, from the birth of a child to a move. Once the disorder is triggered and progresses, 'it seems to develop a life of its own'. State-of-the-art analyses are presented in this new and significant book. The two poles of bipolar disorder are mania and depression.
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Signal Transduction Pathways

These volumes focus on the therapeutic potential for targeting cell signaling mechanisms with particular attention to cancer therapies and inflammatory signaling pathways as well as immunomodulation.

Author: Marc Diederich

Publisher:

ISBN: OCLC:1069488463

Category: Cellular signal transduction

Page: 573

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Ethylene in Plants

This book focuses on recent advances in our understanding of the signal transduction pathway of ethylene, its interaction with other hormones and its roles in biological processes.

Author: Chi-Kuang Wen

Publisher: Springer

ISBN: 9789401794848

Category: Science

Page: 286

View: 787

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This book focuses on recent advances in our understanding of the signal transduction pathway of ethylene, its interaction with other hormones and its roles in biological processes. It discusses at which point plants could have acquired ethylene signaling from an evolutionary perspective. Ethylene was the first gaseous hormone to be identified and triggers various responses in higher plants. Our grasp of ethylene signaling has rapidly expanded over the past two decades, due in part to the isolation of the components involved in the signal transduction pathway. The book offers a helpful guide for plant scientists and graduate students in related areas.
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Advances in Cancer Signal Transduction and Therapy

Key features of this volume include 8 focused topical reviews on signaling pathways in a specific cancer type, coverage of multiple cancer types (breast cancer, colon cancer, hepatocellular cancer, multiple myeloma, acute myeloid leukemia, ...

Author: Manoj K. Pandey

Publisher: Bentham Science Publishers

ISBN: 9789811458095

Category: Medical

Page: 207

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Cancer is driven by numerous genetic and epigenetic changes occurring at the cellular level. These changes drive normal cells to proliferate and escape processes that usually regulate their survival and migration. Many of these alterations are often associated with signaling pathways which regulate cell growth and division, cell death, survival, invasion and metastasis, and angiogenesis. Almost all cancer cells show high expression of signaling components including growth factor receptor tyrosine kinases (RTKs), small GTPases, serine/threonine kinases, cytoplasmic tyrosine kinases, lipid kinases, estrogen receptor, activation of transcription factors Myc and NF-κB, etc. Updated knowledge about these signaling components is highly desirable for researchers involved in developing therapies against cancer. Signal Transduction Research for Cancer Therapy covers advancements in research on the signaling pathways in the human body, especially in some types of cancers, such as breast cancer, pancreatic cancer and colon cancer. Key features of this volume include 8 focused topical reviews on signaling pathways in a specific cancer type, coverage of multiple cancer types (breast cancer, colon cancer, hepatocellular cancer, multiple myeloma, acute myeloid leukemia, and pancreatic cancer), and coverage of a wide array of signaling pathways (both receptor mediated and non receptor mediated pathways). This volume is essential reading for researchers in pharmaceutical R&D and postgraduate research programs in pharmacology and allied disciplines. Clinicians involved in oncology will also benefit from the information provided in the chapters. [Series Intro] This series provides scientists and clinicians with updated clinical information about signal transduction that will be valuable in their pursuit to investigate, develop, and apply novel agents to prevent or treat life-threatening diseases such as cancer. Contributions to the series will focus on methods that also enhance the quality of life for patients.
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Signal Transduction in Mast Cells and Basophils

This book provides a comprehensive summary of the field of signal transduction and provides insights into areas with therapeutic potential.

Author: Ehud Razin

Publisher: Springer Science & Business Media

ISBN: 0387986251

Category: Medical

Page: 423

View: 441

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Mast cells and basophils are responsible for inflammatory and allergic reactions. As such, the signals that generate these responses and how their pathways of action work are the focus of present day research into allergy and inflammation. This book provides a comprehensive summary of the field of signal transduction and provides insights into areas with therapeutic potential.
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Focus on Cellular Signalling Research

Cell signalling is the communication inside a cell or with its environment.

Author: Dorothy T. Leeds

Publisher: Nova Publishers

ISBN: 1594546193

Category: Science

Page: 161

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Cell signalling is the communication inside a cell or with its environment. It plays an important role in cellular growth, survival and apoptosis. For instance, the growth of a cell requires production of certain proteins. The genes that encode these proteins are located in DNA inside the nucleus while the initial signal for cellular growth may come from outside the cell. To induce the expression of these genes, the external signal must pass through specific pathways to reach these genes in DNA. The signalling pathway involves several proteins. If any one of them becomes abnormal or non-functional, the cellular process would be altered, which may cause disease. Therefore, knowing the detailed pathway is very important in understanding the pathogenesis of diseases.
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Signal Transduction Pathways Of Cardiovascular Pathophysiology

Understanding these molecular interactions is not only important for exploring the molecular mechanisms underlying cardiac pathophysiology, but also in the development of novel therapeutics.

Author: Farag Bleiblo

Publisher: LAP Lambert Academic Publishing

ISBN: 3659437662

Category:

Page: 84

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Cardiovascular diseases are life-threatening conditions which can develop through the misregulation of complex cellular signaling networks. Several surveillance mechanisms have evolved to discriminate self from foreign nucleic acids and accordingly trigger effective cellular responses to target the pathogenic threats. Several efforts have been made to understand the role of pattern recognition receptors (PRRs) and nucleic acids in this condition. Understanding these molecular interactions is not only important for exploring the molecular mechanisms underlying cardiac pathophysiology, but also in the development of novel therapeutics. The application of interdisciplinary approaches that integrate high-throughput genomics, proteomics, biostatistics, and computational biology will open avenues to novel multi-hit therapeutic approaches for cardiac diseases. Here, we describe the current knowledge in nucleic acids research in relation to their discrimination, immune activation, and signaling pathways and their potential to cause cardiac pathophysiology.
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Chronic Lymphocytic Leukemia Research Focus

It is believed that BCR plays a role in receptor expression and signal transduction by linking the antigen - binding Ig chains to intracellular tyrosine ...

Author: Chadi Nabhan

Publisher: Nova Publishers

ISBN: 1600215262

Category: Medical

Page: 226

View: 335

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Chronic lymphocytic leukaemia (or "chronic lymphoid leukaemia"), known for short as CLL, is a type of leukaemia in which too many lymphocytes are produced. Although the malignant lymphocytes in CLL may look normal and mature, they are not and these cells may not cope effectively with infection. CLL is the most common form of leukaemia in adults. Men are twice as likely to develop CLL as women. However, the key risk factor is age. Over 75% of new cases are diagnosed in patients over age 50. This book presents important research from around the world in this field.
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Cancer Genetics and Therapeutics

The book discusses cancer and the potential use of phytochemicals as cancer therapeutics.

Author: Madhumita Roy

Publisher: Springer Nature

ISBN: 9789811394713

Category: Medical

Page: 227

View: 316

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The book discusses cancer and the potential use of phytochemicals as cancer therapeutics. It begins with the basics of cancer, including the definition, types, etiology and molecular mechanisms involved, before discussing the fundamentals of diagnosis, treatment and associated problems as well as remedial measures. Since cancer is not a single disease, and the mechanisms of carcinogenesis are different for different cancers, it examines the genes and proteins involved in carcinogenesis, and signal transduction pathways for each individual cancer type. Further, the book reviews the latest research on phytochemicals for cancer treatment, highlighting their anti-cancer properties, sources, structure, active biomolecules and probable mechanisms of action, and describing their biochemical properties in the context of cancer prevention and treatment.
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Helicobacter pylori Research

This book provides the current updated knowledge on all essential aspects in the rapidly evolving area of Helicobacter pylori research. H. pylori is a class I carcinogen and one of the most common infections in the world.

Author: Steffen Backert

Publisher: Springer

ISBN: 9784431559368

Category: Medical

Page: 613

View: 680

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This book provides the current updated knowledge on all essential aspects in the rapidly evolving area of Helicobacter pylori research. H. pylori is a class I carcinogen and one of the most common infections in the world. While most people colonized by H. pylori will remain asymptomatic, up to 20 % of them may develop serious gastroduodenal disease such as peptic ulcers or gastric cancer. H. pylori is the only known bacterium linked to the development of cancer and consequently is an important focus of research. Outstanding international experts from diverse scientific disciplines contribute here to give detailed insights into the current understanding concerning the physiology and role of this pathogen. Both basic science and clinical research with actual practical consequences are taken into account. The chapters target microbiology, epidemiology, genetics, biochemistry, interactions with the immune system, signal transduction, pathogenic mechanisms in the gastroduodenal mucosa, gastric disease development, and therapy including antibiotics or probiotics treatment as well as vaccination strategies. This book is an important reference not only for clinicians but also microbiologists. It provides in a single volume an up-to-date summary of our current knowledge of this microbe and the multiple ways in which it impacts upon public health in all parts of the world.
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Postdoctoral Research Fellowship Opportunities

Specific areas of research include : studies on cellular signaltransduction mechanisms with emphasis on the functions of guanine nucleotide - dependent ...

Author: National Institutes of Health (U.S.)

Publisher:

ISBN: PURD:32754063943298

Category: Health

Page:

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Hepatitis B Virus Research Focus

Hepatitis B virus (HBV), discovered in 1966, infects more than 350 million people in the world.

Author: Xiaodong Zhang

Publisher: Nova Biomedical

ISBN: 1604562994

Category: Medical

Page: 138

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Hepatitis B virus (HBV), discovered in 1966, infects more than 350 million people in the world. The infection of HBV is a leading cause of chronic carriage of the virus and progressive liver diseases, such as hepatitis, liver cirrhosis and hepatocellular carcinoma (HCC). HBV consists of a circular, partially double-stranded DNA molecule of 3.2 kb in length, which contains four overlapping reading frames that code for surface proteins (HBsAg), core proteins (HBcAg/HBeAg), the viral polymerase, and the transcriptional transactivator X protein. Chronic hepatitis appears to be due to a suboptimal cellular immune response that destroys some of the infected hepatocytes and does not purge the virus from the remaining infected hepatocytes, thereby permitting the persisting virus to trigger a chronic indolent necroinflammatory liver disease that sets the stage for development of HCC. However, the mechanisms responsible for malignant transformation in chronic HBV infection are not well defined, and both viral and host factors have been implicated in the process. All cases of HCC occur after many years of chronic hepatitis which could, theoretically, provide the mitogenic and mutagenic environment to precipitate random genetic and chromosomal damage, and lead to the development of HCC. Hepatitis B virus X protein (HBx), an important transforming inducer, plays a crucial role in HCC development. HBx has the capability to influence a variety of signal transduction pathways within the cells. Monitoring of the HBV genotypes and antibody to Hepatitis B x antigen (anti-HBx) are significant for predicting early diagnosis of liver cirrhosis and HCC. HBV and Hepatitis C virus or HIV coinfections can accelerate the course of chronic liver disease and facilitate progression to cirrhosis and HCC. As for therapy of liver diseases, five drugs are now FDA-approved for the treatment of HBV, including interferon (IFN), lamivudine, adefovir, entecavir, and peginterferon alfa-2a. Moreover, the prevention for HBV infection is very important. It is likely that the most important outcome of the research on HBV has been the invention, development, and application of the vaccine against HBV. However, at present most investigators focus on basic research rather than practical applications. The HBV research should be focused on animal models and clinical practice. The technology update in HBV research and the multisubject combination may be attached importance to next a few decades. Some molecular approaches, such as antisense, oligonucleotides, ribozymes, RNA interference targeting HBV mRNA, are available in antiviral therapies.
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Antisense Elements genetics Research Focus

from other cases such as UPR and the inflammatory cytokines TNF - a , LT - a , IL - lą IL - 1B , etc. because these signal transduction pathways diverge to ...

Author: A. G. Hernandes

Publisher: Nova Publishers

ISBN: 1600214916

Category: Medical

Page: 226

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Antisense molecules interact with complementary strands of nucleic acids, modifying expression of genes. Some regions within a double strand of DNA code for genes, which are usually instructions specifying the order of amino acids in a protein along with regulatory sequences, splicing sites, non-coding introns and other complicating details. For a cell to use this information, one strand of the DNA serves as a template for the synthesis of a complementary strand of RNA. The template DNA strand is called the transcribed strand with antisense sequence and the mRNA transcript is said to be sense sequence (the complement of antisense). Because the DNA is double-stranded, the strand complementary to the antisense sequence is called non-transcribed strand and has the same sense sequence as the mRNA transcript (though T bases in DNA are substituted with U bases in RNA). This book presents important new research from around the world in this field.
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Handbook of Cell Signaling

The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field.

Author: Ralph A. Bradshaw

Publisher: Academic Press

ISBN: 9780080920917

Category: Science

Page: 3048

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Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field
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Focus on Colorectal Cancer Research

Recent epidemiological and experimental studies have associated the increased ... Growth factors hormones dietary factors W w Signal transduction cascades Y ...

Author: Julia D. Martinez

Publisher: Nova Publishers

ISBN: 1594541019

Category: Medical

Page: 327

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In Western countries, cancer of the large intestine and rectum (colorectal cancer) is the second most common type of cancer and the second leading cause of cancer death (after lung cancer). The incidence of colorectal cancer begins to rise at age 40 and peaks between ages 60 and 75. Cancer of the large intestine (colon cancer) is more common in women; rectal cancer is more common in men. About 5 percent of the people with colon or rectal cancer have more than one cancer of the colorectum at the same time. People with a family history of colon cancer have a higher risk of developing the cancer themselves. A family history of familial polyposis or a similar disease also increases the risk of colon cancer. People with ulcerative colitis or Crohn's disease have a higher risk of developing cancer. The risk is related to the person's age when the condition developed and the length of time the person has had the condition. Diet plays some role in the risk of colon cancer, but exactly how it affects risk is unknown. Throughout the world, people at highest risk tend to live in cities and eat a diet typical of affluent Westerners. Such a diet is low in fibre and high in animal protein, fats, and refined carbohydrates such as sugar. Risk seems to be reduced by a diet high in calcium, vitamin D, and vegetables such as brussel sprouts, cabbage, and broccoli.
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Signal Transduction Pathways Part B

These volumes focus on the therapeutic potential for targeting cell signaling mechanisms with particular attention to cancer therapies and inflammatory signaling pathways as well as immunomodulation.

Author: Marc Diederich

Publisher: Wiley-Blackwell

ISBN: UVA:X030205322

Category: Medical

Page: 573

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Keynote speakers at the cell signaling meeting in Luxembourg have provided chapters on hypoxia signal transduction, phosphoserine/threonine-binding domains, targeting of polycomb repressive complexes, conserved signaling mechanisms in innate immunity, and signal transduction by stress-activated MAP kinases. Other topics included among these reports on recent research are receptor signaling, protein kinase cascades as therapeutic targets, cell death in cancer, inflammation-specific signaling, cell signaling pathways leading to regulated chromatin modifications, and transcriptional control. The chapters have been published in four volumes (Part A to D), offering a comprehensive overview about this exciting topic. This second volume focuses on basic research, and the chapters are divided into the following sections: oxidative stress, transcriptional control, HDAC, and novel technological and therapeutic approaches. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member
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Research Focus on Natural Products and the Body s Immune and Inflammatory Systems

As oxygen free radicals and other reactive oxygen species appear to be involved in up - regulation of cellular signal transduction and gene activation ...

Author: Kyoungho Suk

Publisher: Nova Publishers

ISBN: 1600217516

Category: Health & Fitness

Page: 313

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The definition of 'natural' is 'produced or existing in nature.' Natural products refer to as any natural constituents, natural substances, or a group of the secondary metabolites that derive from plants, insects, marine plants and animals through their own metabolic pathways. Natural products are usually of high value and small quantity, and they have a variety of biological activities. Extensive research has been performed to understand the effects of natural products on the immune and inflammatory systems. However, the results have been published individually focusing on a particular aspect of immunity or inflammation. The readers in this field may benefit from a comprehensive review book that describes different aspects of immune/inflammatory responses together. This book provides an overview of how a variety of naturally occurring compounds may influence the body's immune and inflammatory systems with an emphasis on the actions of medicinal herbs. In this book, experts in each field present their recent data on the mechanisms by which natural products influence the immune and inflammatory responses. The experimental results that are described in this book are based on various in vitro as well as in vivo model systems. It is also discussed how such effects of natural products are related with their therapeutic applications for the treatment of immune and inflammatory diseases.
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Focus on Breast Cancer Research

A large number of extracellular signals are transmitted through signaling transduction pathways via G proteins ( ras proteins ) in the signal transduction ...

Author: Andrew P. Yao

Publisher: Nova Publishers

ISBN: 1590339614

Category: Medical

Page: 292

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Breast cancer is a malignant tumour that has developed from cells of the breast. A malignant tumor is a group of cancer cells that may invade surrounding tissues or spread (metastasize) to distant areas of the body. The disease occurs almost entirely in women, but men can get it as well. The main types of breast cancer are ductal carcinoma in situ, invasive ductal carcinoma, lobular carcinoma in situ, invasive lobular carcinoma, medullary carcinoma, and Paget's disease of the nipple. About 1 of 8 women will get it in her lifetime. This new book presents state-of-the-art research in this fast-moving field.
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