Inflammatory Disorders of the Nervous System

Cutting-edge and authoritative, Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management offers basic research and clinical scientists an illuminating introduction to the new world of inflammatory CNS ...

Author: Alireza Minagar

Publisher: Springer Science & Business Media

ISBN: 9781588294241

Category: Medical

Page: 372

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A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.
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Immunological and Inflammatory Disorders of the Central Nervous System

The clinical features, immunological background and treatment of these primary and secondary disorders of the CNS are the subject of this book.

Author: Neil Scolding

Publisher: Butterworth-Heinemann Medical

ISBN: UOM:39015042796824

Category: Medical

Page: 264

View: 999

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A variety of diseases which are driven by immunological and inflammatory disturbances can affect the central nervous system; some are primary neurological conditions, e.g. multiple sclerosis, whilst other CNS diseases reflect an inflammatory disorder, e.g. vasculitis. The clinical features, immunological background and treatment of these primary and secondary disorders of the CNS are the subject of this book.
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Inflammatory Disorders of the Nervous System

Not only can the clinical presentation be obscure, there is the differentiation of primary central nervous system ... to be a not uncommonly encountered component of the differential diagnosis in the inflammatory disorders of the CNS.

Author: Alireza Minagar

Publisher: Humana Press

ISBN: 9783319512204

Category: Medical

Page: 281

View: 591

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This thoroughly updated edition covers all clinical aspects of neuroinflammation. The latest developments in pathogenesis and advances in treatment are provided, along with an understanding of the immune system's role and interactions between the activated immune cells, cerebral endothelial cells, and other main components of the immune cascade. Cutting-edge and authoritative, this volume offers practitioners a valuable resource for research and clinical practice.
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Biomarkers of Neuroinflammation

The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from ...

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

ISBN: 9780309463652

Category: Medical

Page: 89

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Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.
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Neuroinflammation and CNS Disorders

The first section of the book highlights the basic concepts in the field whilst the second section, the main body of the book, covers the role of the immune response in specific disorders of the central nervous system.

Author: Nicola Woodroofe

Publisher: John Wiley & Sons

ISBN: 9781118406540

Category: Medical

Page: 424

View: 628

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The last decade has seen an upsurge of information on the role of immune responses in neurodegenerative disorders. In many of these diseases it is still unclear whether the innate and adaptive responses are pathogenic or play a role in repair, and thus understanding their precise roles is key to controlling these diseases by designing immune-therapeutic approaches. The connection between many neurological diseases is the realisation that the immune and nervous systems are inextricable linked, and that perturbations in this delicate balance are involved in many disorders. This has opened up new avenues for therapeutic approaches to treatment of CNS inflammatory and neurodegenerative disorders. Neuroinflammation and CNS Disorders brings together the very latest information on the interactions between the immune system and central nervous system. The first section of the book highlights the basic concepts in the field whilst the second section, the main body of the book, covers the role of the immune response in specific disorders of the central nervous system. Neuroinflammation and CNS Disorders will provide an invaluable guide for both researchers and clinicians working in this complex and dynamic field.
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Inflammatory and Autoimmune Disorders of the Nervous System in Children

Dollfus H, Hafner R, Hofmann HM et al, the International Chronic Infantile Neurological Cutaneous and Articular/Neonatal Onset Multisystem Inflammatory Disease (CINCA/NOMID) Ocular Study Group (2000) Chronic Infantile neurological ...

Author: Russell C. Dale

Publisher: John Wiley & Sons

ISBN: 9781898683667

Category: Medical

Page: 521

View: 261

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Inflammatory disorders of the nervous system, although individually uncommon, collectively make up 10-20% of acute paediatric neurology presentations and many are potentially treatable. Research into them is lagging behind adult research, but better diagnosis and often simple treatments could lead to substantial clinical benefit and reduction in long-term disability. This book provides a detailed and comprehensive summary of the childhood diseases that are, or are likely to be, caused by the immune system. The authors not only describe these disorders and their treatments comprehensively, helping pediatricians and pediatric neurologists to improve their understanding and recognition of the conditions, but also highlight recent and exciting developments that will be of considerable importance in the future.
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Clinical Neuroimmunology

Following this are two chapters that examine distinct aspects of autoimmune disorders of the peripheral nervous system.

Author: Syed A. Rizvi

Publisher: Springer Nature

ISBN: 9783030244361

Category: Medical

Page: 353

View: 969

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This comprehensive, up-to-date book is designed to make recent developments in neuroimmunology accessible to medical professionals in the field. The field of neuroimmunology is complex and rapidly evolving, especially with the current improvements in targeted biologic therapies. This resource concisely offers clear explanations of these scientific and clinical advancements. Divided into five parts, the book begins with an in-depth introduction to neuroimmunology and the principles of immunotherapy. Section two consists of eight chapters devoted to multiple sclerosis, including discussions on the clinical features of the disease as well as symptom management and diagnosis. Subsequent chapters then dive into other central nervous system inflammatory disorders such as neuromyelitis optica, autoimmune encephalopathies, and immunological aspects of cancer. Following this are two chapters that examine distinct aspects of autoimmune disorders of the peripheral nervous system. Finally, the book closes with a review on the neurologic manifestations, diagnostic approaches and treatments of the various systemic rheumatic diseases. Following its successful predecessor edition, Clinical Neuroimmunology: Multiple Sclerosis and Related Disorders, Second Edition is positioned to be an invaluable asset to neurologists, residents and fellows, internists, and general practitioners who treat patients with neurologic disorders and other systemic autoimmune diseases.
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Inflammatory Diseases of the Central Nervous System

This authoritative book defines the key cellular players in mounting an inflammatory response and highlights critical factors in the target organ that influence the nature of that response and its capacity either to damage or protect the ...

Author: Trevor Kilpatrick

Publisher: Cambridge University Press

ISBN: 0521888743

Category: Medical

Page: 282

View: 417

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Interactions between the immune and nervous systems are involved in many disease processes. Modulation of inflammation can provide an important opportunity to enhance regeneration within the central nervous system. This authoritative book defines the key cellular players in mounting an inflammatory response and highlights critical factors in the target organ that influence the nature of that response and its capacity either to damage or protect the brain. Several key clinical areas are highlighted - particularly autoimmune diseases of the nervous system including multiple sclerosis, as well as microbiological and traumatic challenges; the book therefore provides both a summary of the basic science background as well as practical, clinical-friendly guidelines to management. The book will be of interest to a wide range of physicians, including neurologists, neurosurgeons, neurorehabilitationists, infectious disease physicians, and clinical neuroscientists, as well as neuroscientists and immunologists.
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Nanomedicine

This volume in the Methods in Enzymology series comprehensively covers Cancer, Cardiovascular and the central nervous system of Nanomedicine.

Author:

Publisher: Academic Press

ISBN: 9780123918710

Category: Medical

Page: 486

View: 696

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This volume in the Methods in Enzymology series comprehensively covers Cancer, Cardiovascular and the central nervous system of Nanomedicine. With an international board of authors, this volume is split into sections that cover subjects such as Diabetes and nanotechnology as potential therapy, Nanomedicines for inflammatory diseases, and Development and use of ceramide nanoliposomes in cancer. Comprehensively covers cancer and the cardiovascular and central nervous systems of nanomedicine An international board of authors Split into sections that cover subjects such as diabetes and nanotechnology as potential therapy, nanomedicines for inflammatory diseases, and the development and use of ceramide nanoliposomes in cancer
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