Microfluidic Devices for Biomedical Applications

This book is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries.

Author: Xiujun James Li

Publisher: Woodhead Publishing

ISBN: 9780128227558

Category: Medical

Page: 722

View: 917

Download →

Microfluidic Devices for Biomedical Applications, Second Edition provides updated coverage on the fundamentals of microfluidics, while also exploring a wide range of medical applications. Chapters review materials and methods, microfluidic actuation mechanisms, recent research on droplet microfluidics, applications in drug discovery and controlled-delivery, including micro needles, consider applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds, and cover the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis. This book is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries. Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores a wide range of medical applications Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies Details applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and its role in developing tissue scaffolds, and stem cell engineering
Posted in:

Biomedical Applications of Microfluidic Devices

This book covers high-impact fields (microarrays, organ-on-a-chip, pathogen detection, cancer research, drug delivery systems, gene delivery, and tissue engineering) and shows how microfluidics is playing a key role in these areas, which ...

Author: Michael R. Hamblin

Publisher: Academic Press

ISBN: 9780128187920

Category: Technology & Engineering

Page: 350

View: 607

Download →

Biomedical Applications of Microfluidic Devices introduces the subject of microfluidics and covers the basic principles of design and synthesis of actual microchannels. The book then explores how the devices are coupled to signal read-outs and calibrated, including applications of microfluidics in areas such as tissue engineering, organ-on-a-chip devices, pathogen identification, and drug/gene delivery. This book covers high-impact fields (microarrays, organ-on-a-chip, pathogen detection, cancer research, drug delivery systems, gene delivery, and tissue engineering) and shows how microfluidics is playing a key role in these areas, which are big drivers in biomedical engineering research. This book addresses the fundamental concepts and fabrication methods of microfluidic systems for those who want to start working in the area or who want to learn about the latest advances being made. The subjects covered are also an asset to companies working in this field that need to understand the current state-of-the-art. The book is ideal for courses on microfluidics, biosensors, drug targeting, and BioMEMs, and as a reference for PhD students. The book covers the emerging and most promising areas of biomedical applications of microfluidic devices in a single place and offers a vision of the future. Covers basic principles and design of microfluidics devices Explores biomedical applications to areas such as tissue engineering, organ-on-a-chip, pathogen identification, and drug and gene delivery Includes chemical applications in organic and inorganic chemistry Serves as an ideal text for courses on microfluidics, biosensors, drug targeting, and BioMEMs, as well as a reference for PhD students
Posted in:

3D Printed Microfluidic Devices

Toh, Y.-C.; Lim, T.C.; Tai, D.; Xiao, G.; van Noort, D.; Yu, H. A microfluidic 3D hepatocyte chip for drug toxicity testing. ... [CrossRef] [PubMed] Fujii, T. PDMS-based microfluidic devices for biomedical applications. Microelectron.

Author: Savas Tasoglu

Publisher: MDPI

ISBN: 9783038974673

Category:

Page: 211

View: 387

Download →

This book is a printed edition of the Special Issue "3D Printed Microfluidic Devices" that was published in Micromachines
Posted in:

Micro nanoparticle Synthesis by Microfluidic Devices for Biomedical Applications

Author: Lung-Hsin Hung

Publisher:

ISBN: 0549386432

Category: Fluidic devices

Page: 202

View: 855

Download →

Microfluidic systems have advantages such as low sample consumption, fast reaction over conventional bench top processes and were demonstrated the abilities to generate high quality droplets and particles with narrow size distribution. Divided by material category, recent development of using microfluidic devices for semiconductor, metal, colloidal, and biomaterial particle synthesis were reviewed. Microfluidic systems were designed and fabricated accordingly by applications and upon surface modification for droplet generation and particle synthesis purpose. Poly (dimethylsiloxane) and solvent compatible thiolene adhesive were used as device materials, and soft lithography and molding method were utilized for fast device fabrication. Droplet generation and manipulation were demonstrated in microchannels with adjustable generation rate, size, ratio, and controllable droplet fusion and switch. Base on microfluidic systems and droplet technique, three methods, chemical reaction, solvent evaporation, solvent extraction were applied to generate cadmium sulfide and poly (lactide-co-glycolide) micro/nanoparticles. The sizes of synthesized particles range from 5nm (CdS) to 160mum (PLGA) in diameter with narrow size distribution. By utilizing microfluidic platforms more novel particle synthesis can be prepared and applied for drug delivery and biomedical applications.
Posted in:

Diamond based materials for biomedical applications

This chapter discusses the possibilities and advantages offered by the use of diamond materials in the fabrication of microfluidic devices.

Author: A. Karczemska

Publisher: Elsevier Inc. Chapters

ISBN: 9780128088074

Category: Technology & Engineering

Page: 296

View: 756

Download →

This chapter discusses the possibilities and advantages offered by the use of diamond materials in the fabrication of microfluidic devices. The correct choice of material with optimal properties is crucial in the design of modern microfluidic devices. The different applications of diamond materials in this field are reviewed, along with a discussion of recent development and future trends.
Posted in:

Biomedical Applications for Microfluidic Devices

My thesis research has focused on the biomedical applications of microfluidic devices, including accommodating liquid intraocular lens, wirelessly powered dielectrophoresis microfluidic platform, and evaporative microarray for molecular in ...

Author: Wen Qiao

Publisher:

ISBN: 1303627868

Category:

Page: 129

View: 204

Download →

My thesis research has focused on the biomedical applications of microfluidic devices, including accommodating liquid intraocular lens, wirelessly powered dielectrophoresis microfluidic platform, and evaporative microarray for molecular in-vitro diagnosis. In the first part, I developed an accommodating intraocular lens that can largely improve cataract patients' living quality by enabling patients to focus on far distance as well as near distance. Compared to natural eyes, today's commercially available accommodating IOLs produce a much limited tuning range. The large performance gap is attributed to the fundamental difference between crystalline lens and the optic-shift IOLs in the operation principles. In the thesis we designed and made a fluidic IOL that can change its curvature as the crystalline lens does. Both mechanical performance and optical quality are tested under the physiological conditions of aged eyes, promising complete restoration of vision accommodation. In the second part, I reported the first microfluidic device integrated with a printed RF circuit so that the device can be wirelessly powered by a commerciallyavailable radio-frequency identification (RFID) reader. The device eliminates the need for wire attachments and external instrument, so the operators can use the device in essentially the same manner as they do with microscope slides. The integrated circuit can be fabricated on a flexible plastic substrate at very low cost using a roll-to-roll printing method. Electrical power at 13.56 MHz transmitted by a RFID reader is inductively coupled to the printed RFIC and converted into 10V DC (direct current) output, which provides sufficient power to drive a microfluidic device to manipulate biological particles such as beads and proteins via the DC dielectrophoresis (DC-DEP) effect. In the third part, I developed a mathematical model for microarray probe/target reaction. The analysis was based on any chemical reaction between target molecules suspended in solution react and probes immobilized on a solid substrate, so it can be used to analysis hybridization efficiency in genomic microarray, as well as binding efficiency in protein microarray. The model indicated that besides diffusion, electrical repelling force between negatively charged probe and target molecules is the main cause for low hybridization efficiency. Based on the model, we further proposed a novel evaporative microarray, which can reduce the target solution thickness down to 80 [mu]m and theoretically enrich the concentration of molecules up to 1000 fold before target/probe chemical reaction. Preliminary data demonstrated the feasibility of integration of evaporation with microarray using black silicon template.
Posted in:

Microfluidic Chip Capillary Electrophoresis Devices

Guo, W.P., Lau, K.M., Sun, H. and Fung, Y.S. Microfluidic chip-capillary electrophoresis for emergency onsite biomedical analysis. Sep Sci 2010, 2, 3–10. Fung, Y.S. Microchip-capillary electrophoresis for biomedical application in Hong ...

Author: Ying Sing Fung

Publisher: CRC Press

ISBN: 9781482251654

Category: Science

Page: 396

View: 650

Download →

Capillary electrophoresis (CE) and microfluidic chip (MC) devices are relatively mature technologies, but this book demonstrates how they can be integrated into a single, revolutionary device that can provide on-site analysis of samples when laboratory services are unavailable. By introducing the combination of CE and MC technology, Microfluidic Ch
Posted in: