Designed to simplify pharmacokinetics to help busy practitioners understand and visualize basic principles, the easy-to-read, case-study format has made the text a favorite among clinical professors, students, and practitioners. The text provides an introduction to the principles of monitoring drug therapy for those involved in the interpretation of drug levels in a patient care setting. Part One provides a basic review of pharmacokinetic principles. Part Two explains the clinical applications of these principles. Appendices provide commonly used equations and a glossary of pharmacokinetic terms and abbreviations.
Designed to simplify pharmacokinetics to help busy practitioners understand and visualize basic principles, the easy-to-read, case-study format has made the text a favorite among clinical professors, students, and practitioners.
Author: Michael E. Winter
Publisher: Lippincott Williams & Wilkins
Winter's Basic Clinical Pharmacokinetics helps readers apply pharmacokinetics and therapeutic drug monitoring to patient care. An easy-to-read, case-study format has made this text a favorite among students and clinicians. Divided into two parts, Part I reviews basic pharmacokinetic principles, and Part II illustrates the clinical application of these principles to common problems. Extensive explanations emphasize major concepts and accompany complex equations. Figures help visualize concepts NEW chapters include drug dosing in renal disease, pediatric considerations, and pharmacogenomics, as well as antifungals and expansion of the cytotoxic and immunosuppressant therapies Includes cases that address pediatric considerations and pharmacogenomics Updates include new information on the clinical use of serum drug concentrations New Learning Objectives at the beginning of each chapter highlight the key concepts
Part II explains the clinical applications of these principles to problems commonly encountered in the practice setting with specific drugs. This edition includes the latest information on the clinical use of serum drug concentrations.
Author: Paul Beringer
Designed as a portable companion to Michael E. Winter's classic text, Basic Clinical Pharmacokinetics Handbook is a must for busy practitioners who need a fast-access reference to the specific parameters and equations required for pharmacokinetic evaluations. Part One of the handbook provides common pharmacokinetic equations along with discussions on choosing the appropriate equation for a given situation. Basic pharmacokinetic principles, assessment of renal function, and dialysis of drugs are also discussed in detail. Part Two presents pharmacokinetic data for specific drugs, including aminoglycosides, carbamazepine, cyclic antidepressants, cyclosporine, digoxin, ethosuximide, lidocaine, lithium, methotrexate, phenobarbital, phenytoin, procainamide, primidone, quinidine, salicylates, theophylline, valproic acid, and vancomycin. Appendices contain common abbreviations and a glossary of pharmacokinetic terms.
Part One of the handbook provides common pharmacokinetic equations along with discussions on choosing the appropriate equation for a given situation.
Author: John R. White (Jr.)
Publisher: Applied Therapeutics
Compiled by internationally recognized experts in trauma critical care,this sourcediscusses the entire gamut of critical care management of the trauma patient and covers several common complications and conditions treated in surgical intensive care units that are not specifically related to trauma. Utilizing evidence-based guidelines where they ex
Winters ME. Vancomycin. Basic Clinical Pharmacokinetics. 3rd ed. Vancouver,
WA: Applied Therapeutics, Inc., 1994:474–499. Hess MM, Boucher BA, Laizure
SC, et al. Trimethoprimsulfamethoxazole pharmacokinetics in trauma patients.
Author: William C. Wilson
Publisher: CRC Press
Pharmacologists can be considered pioneers of the study of kinetics of materials introduced into biological systems. The study of drug kinetics is particularly suited to a formulation of relatively simple models which make possible an interpretation of the time-dependent nature of various important phenomena (e. g. distribution by means of diffu sion through membranesl. The objective of the NATO ASI Course on Pharmacokinetics was that of presenting and dis cussing the mathematical and statistical approaches current ly available or being developed for the description, inter pretation and prediction of the fate of drugs and tracer substances administered to living beings. Different physi cal methods for measuring drugs and tracer substances were considered, but the emphasis was on the interpretation of the results of the measurements in terms of mathematical and statistical models. The present book contains all invit ed lectures given in this Course by outstanding internation al authorities and specialists from different fields. A great effort was made to keep a balance among the mathemati cal, physical, biological and clinical aspects of the prob lems; exchange of ideas and experiences between scientists with a physico-mathematical background and scientists with a biomedical background was encouraged and all participants were deeply involved in fruitful discussions. This unique feature of the Course is also the unique characteristic of this book which is therefore mainly directed to people interested not just in acquiring a working knowledge of the methods but in developing new methods.
M. E. Winter, "Basic Clinical Pharmacokinetics," Applied Therapeutics, Inc., San
Francisco, p. 20-22, p. 48-50 (1980). 5. M.E. Winter, personal communication. 6.
M. Rowland and T. Tozer, "Clinical Pharmacokinetics: Concepts and Applications
Author: A. Pecile
Publisher: Springer Science & Business Media
A practical guide to the use of pharmacokinetic principles in clinical practice. Over 30 clinical cases with self-study questions and answers are presented throughout to bridge the gap between pharmacokinetic concepts and their practical application to individual patients. Pharmacokinetics is the study of the process of drug absorption, distribution, metabolism and elimination. The aim of applying pharmacokinetic principles is to individualise the dose of drug, and optimise the outcome achieved in each patient. Its application reduces the chance of under-treatment, inadvertent poisoning and dose related adverse effects.
Smith H W , ed . ( 1951 ) . The Kidney : Structure and Function in Health and
Disease . New York : Oxford University Press , 231-238 . Winter M E ( 2003 ) .
Basic Clinical Pharmacokinetics , 4th edn . Philadelphia : Lippincott Williams and
Author: Soraya Dhillon
Publisher: Pharmaceutical Press
This first volume of an exciting new book series offers a comprehensive and logically organized introduction to clinical pharmacy as applied to renal medicine. The volume opens with a review of renal pharmacokinetics: absorption; distribution; metabolism; and elimination, as well as drug dosing in renal impairment, and important knowledge specific to aging and renal impairment. Acute kidney injury receives extensive attention, including pre-renal, intra-renal, and post-renal injuries. The book also outlines the role of clinical pharmacy in chronic kidney disease and end stage renal failure. Additional chapters provide detailed information on the methods and pharmacokinetics of renal dialysis, and the epidemiology and management of drug-induced nephrotoxicity. The Advanced Clinical Pharmacy series provides a review of core pharmaceutical concepts, a foundation for optimizing pharmacotherapy, and an introduction to advanced clinical practice. The editors and contributors are international experts who distill the core knowledge of each specialty. The books offer real-world insights to benefit both new practitioners, and experienced pharmacists exploring new areas of clinical pharmacy
2.10 Pharmacokinetics and Pharmacodynamics Pharmacokinetics (PK) is the
effect the body has on the drug, whereas pharmacodynamics (PD) is the effect
the drug has on the body. ... Winter's basic clinical pharmacokinetics. 6th ed.
Author: Rhiannon Braund
Publisher: Springer Nature
This volume is the third in a series of succinct, analytical reviews of advances in the psychiatric care of medically ill patients. Like the previous volumes, Medical-Psychiatric Practice, Volume 3 is designed to continually update the busy clinician on research and practical developments in medical psychiatry. Under the guidance of an eminent editorial advisory board, this volume addresses several specific clinical problems that require an integrated medical-psychiatric approach to their diagnosis and treatment. It includes an in-depth discussion of psychopharmacokinetics as well as an update on psychopharmacology in medically ill patients.
Philadelphia , PA , WB Saunders , 1979 , pp 1060–1086 Winter ME : Basic
principles , in Basic Clinical Pharmacokinetics , 2nd Edition . Edited by Koda -
Kimble MA , Young LY . Spokane , WA , Applied Therapeutics , 1988a , pp 7-99
Author: Alan Stoudemire
Publisher: American Psychiatric Pub
Now in its fifth edition, this best-selling, multidisciplinary textbook continues to draw on the skills of pharmacists and clinicians to present optimal drug regimens. The authors integrate an understanding of the disease processes with an appreciation of pathophysiological processes, clinical pharmacy and the evidence base. New to this edition: Stronger emphasis on understanding both the prescribing process and the clinical pharmacy process. All chapters completely revised and updated. Thirty-eight leading new authors. Features: Key points boxes at the beginning of every chapter Case study tests at the end of every chapter Chapters co-authored by pharmacists and clinicians Organised by body system Consistent, clearly signposted chapter layout ‘...a unique and valuable support for all those involved or interested in drug therapy. This is a textbook that no university or pharmacy department, particularly those with employees studying at any level, and no pharmacist trying to develop their knowledge base should be without." Dr Chris Green and John Sexton, The Pharmaceutical Journal Now in its fifth edition, this best-selling, multidisciplinary textbook continues to draw on the skills of pharmacists and clinicians to present optimal drug regimens. The authors integrate an understanding of the disease processes with an appreciation of pathophysiological processes, clinical pharmacy and the evidence base. New to this edition: Stronger emphasis on understanding both the prescribing process and the clinical pharmacy process. All chapters completely revised and updated. Thirty-eight leading new authors. Features: Key points boxes at the beginning of every chapter Case study tests at the end of every chapter Chapters co-authored by pharmacists and clinicians Organised by body system Consistent, clearly signposted chapter layout ‘...a unique and valuable support for all those involved or interested in drug therapy. This is a textbook that no university or pharmacy department, particularly those with employees studying at any level, and no pharmacist trying to develop their knowledge base should be without." Dr Chris Green and John Sexton, The Pharmaceutical Journal Stronger emphasis on understanding both the prescribing process and the clinical pharmacy process. All chapters completely revised and updated. Thirty-eight leading new authors.
Applied Pharmacokinetics and Pharmacodynamics: Principles of Therapeutic
Drug Monitoring, fourth ed. Lippincott Williams & Wilkins, Baltimore. ... Winter,
M.E., 2003. Basic Clinical Pharmacokinetics. Lippincott Williams & Wilkins,
Author: Roger Walker
Publisher: Elsevier Health Sciences
Tackle your toughest challenges and improve the quality of life and long-term outcomes of your patients with authoritative guidance from Fanaroff and Martin s Neonatal-Perinatal Medicine. Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh and a contributing team of leading experts in the field deliver a multi-disciplinary approach to the management and evidence-based treatment of problems in the mother, fetus and neonate. New chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors keep you current on the late preterm infant, the fetal origins of adult disease, neonatal anemia, genetic disorders, and more. "...a valuable reference book and a pleasure to read." Reviewed by BACCH Newsletter, Mar 2015 Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, multi-disciplinary text in the field! See nuance and detail in full-color illustrations that depict disorders in the clinical setting and explain complex information. Obtain more global perspectives and best practices with contributions from international leaders in the field of neonatal-perinatal medicine. Get comprehensive guidance on treating patients through a dual focus on neonatology and perinatology. Spot genetic problems early and advise parents of concerns, with a completely new section on this topic. Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout. Stay at the forefront of your field thanks to new and completely revised chapters covering topics such as: Principles and Practice l Immune and Non-immune Hydrops Fetalis l Amniotic Fluid Volume l Enhancing Safe Prescribing in the Neonatal Intensive Care Unit l Role of Imaging in Neurodevelopmental Outcomes of High-Risk Neonates l Patent Ductus Arteriosus l Gastroesophageal Reflux and Gastroesophageal Reflux Diseases in the Neonate. Find and grasp the information you need easily and rapidly with indexing that provides quick access to specific guidance.
Nyberg L, Wettrell G. Pharmacokinetics and dosage of digoxin in neonates and
infants. Eur J Clin ... Winter ME. Basic clinical pharmacokinetics. 4th ed.
Philadelphia: Lippincott Williams & Wilkins; 2004. Zhou SF, Di YM, Chan E, et al.
Author: Richard J. Martin
Publisher: Elsevier Health Sciences
Goodman and Gilman ' s The Pharmacologic Basis of Therapeutics . 10th ed .
New York : McGraw - Hill , 2001 . 4 . Phenytoin . In : Winter ME . Basic Clinical
Pharmacokinetics . 4th ed . Philadelphia , PA : Lippincott , Williams and Wilkins ;
Author: John E. Murphy
Publisher: Amer Soc of Health System
Now fully revised and updated, Dr. Barbara Gladson's Pharmacology for Rehabilitation Professionals, 2nd Edition, remains your best resource for understanding how various drugs affect patients during therapeutic exercise and rehabilitation. Using case studies and engaging activities, it helps you apply essential pharmacology information directly to rehabilitation practice. New chapters, a new reader-friendly design, new artwork, and more enhance the text and bring you up to date with both basic pharmacologic principles as well as the mechanism of action and side effects of drugs commonly seen in rehabilitation practice. Helps you develop effective exercise programs by providing drug/exercise interactions from a pharmacokinetics perspective. You willl clearly see the implications for exercise for each specific condition and medication. Presents case studies in every chapter that demonstrate the effects of various drugs on the diagnosis, prognosis, and interventions in physical therapy, so you can more easily monitor patients for adverse drug effects. Features engaging activities in every chapter, ranging from patient interviews to challenging, real-life questions, helping you retain and apply what you've learned. Encourages you to use the latest research in your clinical decision making with evidence-based content incorporated throughout. Simplifies the complex topic of pharmacokinetics so that you will fully understand how it affects your individual patients and your care plans. Guides you in using the Internet for online drug information with references to specific sites, and when and how to use them to their fullest potential. Discusses lifespan considerations such as age, physical differences, and obesity, as well as the latest information on diabetes and glucose testing. A new chapter on Complementary and Alternative Medicine in Pharmacology covers popular herbal and alternative products used to promote health, as well as herbal remedies used during menopause and in the treatment of cancer, helping you recognize the impact of herbals on your patients' symptoms and response to therapy. A new chapter on Drugs Affecting the Integumentary System discusses skin disorders and their pharmacological treatment, prophylactic and debriding agents, antiseptics, and more. A new chapter on Nutrition and Pharmacology provides current information on vitamins and minerals, enteral and parenteral nutrition, and food and drug interactions -- important topics that affect rehabilitation outcomes. Updated drug information and new drugs are added throughout the text, keeping you up to date with current pharmacological information as it pertains to rehabilitation.
How is each phase of pharmacokinetics influenced by the patient's medical
condition? What should be ... In Katzung BG, editor: Basic and clinical
pharmacology, New York, 2007, McGraw-Hill. 5. ... Winter ME: Basic clinical
Author: Barbara Gladson
Publisher: Elsevier Health Sciences
A STEP-BY-STEP APPROACH TO DESIGNING ACCURATE DOSING REGIMENS Casebook in Pharmacokinetics and Drug Dosing uses real-life cases to teach pharmacy students, pharmacists, and clinical pharmacists how to apply pharmacokinetics to formulate proper dosing regimens. In order to be as clinically relevant as possible, the book not only discusses drugs with readily available therapeutic serum levels, but places equal emphasis on high-alert agents with narrow therapeutic indexes. Each drug chapter is written by clinical pharmacists who have hands-on experience in drug dosing and includes an overview of the drug’s pharmacology, including: Indications Mec hanisms of action Toxicities Pharmacokinetics There is comprehensive review and discussion of each drug's bioavailability, volume of distribution, clearance, half-life, therapeutic drug level monitoring, drug interactions, dosing, and availability. Each chapter is enhanced by numerous patient cases with clear step-by-step answers and explanations. Calculations, equations, and dosing recommendations are provided for each case.
Pai AB, Pai MP. Vancomycin dosing in high flux hemodialysis: A limited-sampling
algorithm. Am J Health-Syst Pharm. 2004;61:1812–1816. Ambrose PJ, Winter ME
. Vancomycin. In Winter ME (Ed.). Basic Clinical Pharmacokinetics, 5th ed.
Author: Henry Cohen
Publisher: McGraw Hill Professional
Shargel L , Yu ABC . Applied Biopharmaceutics and Pharmacokinetics . 3rd ed .
Norwalk , CT : Appleton & Lange ; 1993 . Winter ME . Basic Clinical
Pharmacokinetics . 2nd ed . Spokane , WA : Applied Therapeutics ; 1988 .
Author: Gerald E. Schumacher
Publisher: McGraw-Hill/Appleton & Lange
... Oncology Therapeutics ; Drs . Michael Winter , Brian Katcher and Mary Anne
Koda - Kimble , who prepared a text on Basic Clinical Pharmacokinetics ; and Dr.
Thomas Toser co - authored with Dr. Winter a chapter on phenytoin kinetics in the
Author: University of California, San Francisco. School of Pharmacy. Alumni Association
For over 100 years, Remington has been the definitive textbook and reference on the science and practice of pharmacy. This Twenty-First Edition keeps pace with recent changes in the pharmacy curriculum and professional pharmacy practice. More than 95 new contributors and 5 new section editors provide fresh perspectives on the field. New chapters include pharmacogenomics, application of ethical principles to practice dilemmas, technology and automation, professional communication, medication errors, re-engineering pharmacy practice, management of special risk medicines, specialization in pharmacy practice, disease state management, emergency patient care, and wound care. Purchasers of this textbook are entitled to a new, fully indexed Bonus CD-ROM, affording instant access to the full content of Remington in a convenient and portable format.
Paul M Beringer , PharmD Michael E Winter , PharmD In Chapter 58 , the basic
principles of pharmacokinetics were presented . Clinical pharmacokinetics is the
discipline in which basic pharmacokinetic principles are applied to the ...
Author: David B. Troy
Publisher: Lippincott Williams & Wilkins
M . E . Winter , ' Basic Clinical Pharmacokinetics ' , 2nd edn . , Applied
Therapeutics , Spokane , 1988 . 10 . S . Riegelman and P . Collier , J .
Pharmacokinet . Biopharm . , 1980 , 8 , 509 . 11 . M . Rowland and S . Riegelman
, J . Pharm .
Author: Corwin Hansch
( BRIEFLY ) Hot off the press , the first of its kind , and a damn good book : Basic
Clinical Pharmacokinetics . Why mention it here ? The principle author is Mike
Winter , '70 although Brian Katcher , '69 and Mary Anne Koda - Kimble , '69 had a
Includes entries for maps and atlases.
Category: Catalogs, Union
LOUIS B. GOLDSTEIN , '35 , graduate of the School of Medicine and assistant
clinical professor , obstetrics and gynecology ... and MICHAEL E. WINTER , all S /
P : Co - authors , Basic Clinical Pharmacokinetics , Applied Therapeutics , 1980 .